NUTRIENT SUPPORT IN TRANSPLANTATION RESEARCH WORKSHOP

移植研究研讨会中的营养支持

基本信息

批准号：
6050977
负责人：
W SCOTT HELTON
金额：
$ 1.5万
依托单位：
AMERICAN SOCIETY/PARENT & ENTERAL NUTRIT
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-30 至 2000-09-29
项目状态：
已结题

项目摘要

Patients with chronic failure of the pancreas, liver, intestine, kidney, lungs and heart are often malnourished as a result of maldigestion, malabsorption, and poor nutrient assimiliation. This is compounded by the fact that many of these patients have a prolonged catabolic state characterized by increased energy expenditure coupled with anorexia and inadequate dietary intake. Malnourished patients undergoing transplantation have increased morbidity and mortality. Recent investigations demonstrate that single nutrients (e.g. arginine, omega3 fatty acids, pyruvate) or nutritional conditions (e.g. the fasted vs. fed state) can dramatically alter the short and long term function of transplanted organs. Despite these facts, there has been very little organized effort to discuss the roles of nutritional support or potential benefits of specific nutrients on the function of transplanted organs or the outcome of the recipient. To our knowledge there has never been a multidisciplinary focused research conference on the role of nutritional intervention on human transplantation. The main objectives of this conference are to summarize the current state of knowledge in nutritional support of the transplant patient (before and after transplantation) and to discuss novel ways of how nutritional manipulation can modulate the transplant process and improve the outcome of patients. The conference will focus on novel ways of using nutritional support, vitamins and specific nutrients to protect transplanted organs from preservation injury, immunologic rejection and improve their short and long-term function. There is a need to exchange ideas between basic scientists, transplant physicians and nutritionists to review recent advances in transplant biology, the rejection process, pharmacology, preservation solutions and how nutrients and nutritional support practices affect these areas. The proposed conference will select 100 scientists and clinicians from a pool submitting abstracts. We have invited leaders in clinical and experimental transplantation as well as national leaders in nutritional support with a clinical interest in transplant patients. The participants include pioneers in transplantation research, as well as world authorities in clinical transplantation from some of the most prominent transplant centers in the world. In addition, we will invite 11 young investigators to attend the research conference and to present their work in a special interactive forum which will be included in the annual clinical congress of the American Society for Parenteral and Enteral Nutrition. Speakers will present thought provoking new research and refrain from general overviews. Collectively, the talks will encompass the entire field of transplantation and stimulate opportunities not previously considered for improving the art, science and practice of transplantation. We will encourage active discussion between participants about the concepts discussed and identify promising areas for future investigation.

患有胰腺、肝脏、肠、肾、肺和心脏慢性衰竭的患者常常因消化不良、吸收不良和营养吸收不良而营养不良。事实上，许多患者具有长期的分解代谢状态，其特征是能量消耗增加、厌食和饮食摄入不足。接受移植的营养不良患者的发病率和死亡率增加。最近的研究表明，单一营养素（例如精氨酸、omega3 脂肪酸、丙酮酸）或营养条件（例如禁食与进食状态）可以显着改变移植器官的短期和长期功能。尽管存在这些事实，但很少有组织的努力来讨论营养支持的作用或特定营养素对移植器官功能或受体结果的潜在益处。据我们所知，从未召开过关于营养干预对人体移植作用的多学科重点研究会议。本次会议的主要目的是总结移植患者营养支持（移植前和移植后）的知识现状，并讨论营养操作如何调节移植过程和改善患者预后的新方法。会议将重点讨论利用营养支持、维生素和特定营养素来保护移植器官免受保存损伤、免疫排斥并改善其短期和长期功能的新方法。基础科学家、移植医生和营养学家之间有必要交换意见，以回顾移植生物学、排斥过程、药理学、保存解决方案以及营养素和营养支持实践如何影响这些领域的最新进展。拟议的会议将从提交摘要的库中选出 100 名科学家和临床医生。我们邀请了临床和实验移植领域的领导者以及对移植患者临床感兴趣的国家营养支持领域的领导者。参与者包括移植研究的先驱，以及来自世界上一些最著名的移植中心的临床移植领域的世界权威。此外，我们将邀请11位年轻研究者参加研究会议，并在一个特别的互动论坛上展示他们的工作，该论坛将纳入美国肠外和肠内营养学会的年度临床大会。演讲者将介绍发人深省的新研究，而不是进行一般性概述。总的来说，会谈将涵盖整个移植领域，并激发以前未考虑过的改善移植艺术、科学和实践的机会。我们将鼓励参与者就所讨论的概念进行积极讨论，并确定未来研究的有希望的领域。