DEVELOPMENTAL TOXICITY OF METHYLMERCURY

甲基汞的发育毒性

• 批准号: 6074691
• 负责人: THOMAS W CLARKSON
• 金额: $ 38.95万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2001-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6074691
• 关键词: Osteichthyes; child (0-11); clinical research; disease /disorder proneness /risk; embryo /fetus toxicology; environmental toxicology; food contamination; human subject; longitudinal human study; methylmercury; nutrition related tag; pregnancy; seafood; seafood poisoning

DESCRIPTION: The main objective of the application is to better define the human health risks associated with prenatal and early postnatal exposure to methylmercury in fish. Subtle psychological and behavioral changes will be measured and related to the exposure of mothers during pregnancy. The study will be conducted on a cohort of 740 children from a population in the Seychelles Islands, whose diet consists primarily of large amounts of ocean fish. The application will extend the evaluation of developmental toxicity of methylmercury on the cohort to include the age of 7-8 years, which will make it feasible to compare results with those from studies of prenatally exposed infants in New Zealand and the Faeroe Islands. The population used in the longitudinal study presents a wide range in mercury levels so that the results can be applied in assessing the health risks in the U.S. population due to consumption of methylmercury in fish.

描述：应用程序的主要目的是更好地定义 与产前和早期暴露有关的人类健康风险 鱼类中的甲基汞。 微妙的心理和行为改变将是 测量并与怀孕期间母亲的暴露有关。 研究 将以来自740名儿童的人群的同类 塞舌尔群岛的饮食主要由大量海洋组成 鱼。 该应用程序将扩大发育毒性的评估 在队列上的甲基马克里，包括7-8岁的年龄，这将 使将结果与产前研究的结果进行比较 新西兰和法洛群岛的暴露婴儿。 人口使用 在纵向研究中，汞含量广泛，因此 结果可以应用于评估美国的健康风险 由于食用鱼类中的甲基汞而导致的人口。