CARDIAC RENIN/ANGIOTENSIN SYSTEM IN HEART FAILURE

心力衰竭中的心脏肾素/血管紧张素系统

• 批准号: 6208188
• 负责人: LAWRENCE S. ZISMAN
• 金额: $ 5.41万
• 依托单位: ALBANY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6208188
• 关键词: RNA splicing; RNase protection assay; active sites; enalapril; enzyme activity; enzyme inhibitors; gene expression; genetic polymorphism; genotype; heart circulation; heart failure; high performance liquid chromatography; hormone regulation /control mechanism; human subject; intracellular transport; messenger RNA; myocardium disorder; pathologic process; peptide hormone biosynthesis; peptide hormone metabolism; peptidyl dipeptidase A; radioimmunoassay; renin angiotensin system; tissue /cell culture

Several large clinical trials of angiotensin converting enzyme (ACE) inhibitors have demonstrated the critical role of the renin angiotensin system (RAS) in the pathogenesis of heart failure. These trials also indicate an unexplained heterogeneity in response to ACE-inhibitor therapy. The general hypothesis to be tested in this application is that there is variation in ACE activity in the falling human heart. An in vivo protocol using intracoronary 123I-Ang I will be used to study Ang II formation in the intact failing human heart.

血管紧张素转换酶（ACE）多项大型临床试验 抑制剂已证明肾素血管紧张素的关键作用 系统（RAS）在心力衰竭发病机制中的作用。这些试验还 表明对 ACE 抑制剂的反应存在无法解释的异质性 治疗。 本应用中要测试的一般假设是 下降的人类心脏中 ACE 活性的变化。体内实验方案 使用冠状动脉内 123I-Ang I 将用于研究 Ang II 的形成 完好无损的人类心脏。

项目成果

Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes.

在衰竭的人心室肌细胞中选择性激活 N-酰基-D-葡萄糖胺 2-差向异构酶表达。

• DOI: 10.1054/jcaf.2003.6
• 发表时间: 2003
• 期刊: Journal of cardiac failure.
• 作者: Bohlmeyer,Teresa;Ferdensi,Anthony;Bristow,MichaelR;Takahashi,Saori;Zisman,LawrenceS
• 通讯作者: Zisman,LawrenceS

Differential regulation of cardiac angiotensin converting enzyme binding sites and AT1 receptor density in the failing human heart.

• DOI: 10.1161/01.cir.98.17.1735
• 发表时间: 1998-10
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Lawrence S. Zisman;Koji Asano;Darrin L. Dutcher;Anthony Ferdensi;A. Robertson;M. Jenkin;Erik W. Bush;T. Bohlmeyer;M. Perryman;Michael R. Bristow