EXERCISE AND ENERGY/SUBSTRATE UTIL IN BLACKS WITH NIDDM

NIDDM 黑人的锻炼和能量/底物利用率

• 批准号: 2900083
• 负责人: DARA P SCHUSTER
• 金额: $ 11.99万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2900083
• 关键词: African American; aerobic exercise; basal metabolism; bioenergetics; body composition; calorimetry; caucasian American; clinical research; disease /disorder prevention /control; glucose metabolism; human subject; insulin sensitivity /resistance; magnetic resonance imaging; noninsulin dependent diabetes mellitus; obesity; oxidation; pancreatic islets; photon absorptiometry; racial /ethnic difference; thermogenesis

African Americans (AA) have a 2-3 fold higher prevalence of type 2 diabetes mellitus (DM), greater disease-associated morbidity and mortality and earlier age of onset than Caucasian Americans (CA). The etiology for these differences is unclear but has been related to insulin resistance and an increased prevalence of obesity. Thus, investigations into racial differences in metabolic and energy aspects of type 2 DM in AA will provide important data on the increased prevalence of both obesity and type 2 DM in the AA population when compared to CA. The aims of the study include: 1) To examine racial differences in substrate utilization, energy expenditure, insulin sensitivity, glucose effectiveness and beta cell function before and after chronic exercise in AA and CA subjects with type 2 DM, 2) To determine the effects of chronic excercise on the resting metabolic rate (RMR), postprandial thermogenesis and substrate oxidation in CA and AA subjects with type 2 DM, 3) To compare the effects of resistance vs. Aerobic training on substrate oxidation and energy expenditure and 4) to determine whether the sequential pattern of exercise is associated with different metabolic and energy consequences in CA an dAA subjects with type 2 DM. The proposed study is a prospective exercise intervention program in AA and CA subjects with type 2 DM. The study population will consist of 75 AA and 75 CA subjects with type 2 DM. The time frame for study participation will be 26 weeks. On study day 1, each subject will undergo screening laboratory data, assessment of glucose turnover rates with D-3 3H glucose infusion and concomitant IGTT and indirect calorimetry. On study day 2, each subject will have a dual energy x-ray absorptiometry (DEXA) scan and a magnetic resonance imaging (MRI) scan for assessment of body composition and body fat distribution. On study day 3, insulin sensitivity, glucose effectiveness and beta-cell function will be assessed using the Bergman Minimal Model Methodology. The subjects will then be randomly allocated to begin either 8 weeks of aerobic or resistance training with a crossover to the other exercise training program for an additional 8 weeks. Each metabolic and anthropometric study will be prformed four times; upon entry to the study, after completion of each of the exercise programs, and 8 weeks after the exercise intervention. This study will provide insights into the metabolic abnormalities assoicated with type 2 DM in AA and the importance of exercise intervention in the AA and CA population. The findings of the present study could be the basis of prescribing an effective exercise modality in AA patients with type 2 diabetes mellitus. I believe my past experience has prepared me for a career in academic research as an independent investigator. The proposed K08 grant will help me to achieve these goals as wellas become competivitie for Public Health Service and other national funding. This project is a continuum of previous research in which I have been involved while it examines and area of glucose metabolism in which little is known, the racial differences in the effects of exercise on glucose metabolism.

非洲裔美国人（AA）的类型2的患病率更高2-3 糖尿病（DM），与疾病相关的发病率更高和 死亡率和发病年龄比白人美国人（CA）。 这 这些差异的病因尚不清楚，但与 胰岛素抵抗和肥胖症患病率的增加。 因此， 对代谢和能量方面的种族差异的调查 AA中的2型DM将提供有关增加的重要数据 肥胖和2型DM的患病率在AA人群中 与大约相比 研究的目的包括：1）检查种族 底物利用率，能量消耗，胰岛素的差异 敏感性，葡萄糖有效性和β细胞功能和β细胞功能 在具有2型DM的AA和CA受试者中进行慢性运动后，2） 确定慢性运动对静息代谢率的影响 （RMR），餐后热生成和CA和AA中的底物氧化 具有2型DM的受试者，3）比较电阻VS的影响。 关于底物氧化和能量消耗的有氧训练，4） 确定练习的顺序模式是否相关 在CA DAA受试者中具有不同的代谢和能量后果 使用2型DM。 拟议的研究是一项前瞻性练习 具有2型DM的AA和CA受试者的干预计划。 研究 人口将由2型DM的75名AA和75名CA受试者组成。 这 研究参与时间范围将为26周。 在学习第1天， 每个受试者将接受筛查实验室数据，评估 D-3 3H葡萄糖输注和伴随IGTT的葡萄糖更新速率 和间接量热法。 在学习第2天，每个学科都有双重 能量X射线吸收法（DEXA）扫描和磁共振成像 （MRI）扫描以评估人体成分和体内脂肪分布。 在研究第3天，胰岛素敏感性，葡萄糖有效性和β细胞 将使用Bergman最小模型方法来评估功能。 然后，受试者将随机分配以开始任意8周 有氧或抵抗训练与另一个练习交叉 培训计划额外8周。 每个代谢和 人体测量学研究将四次预定；进入 研究，每个练习计划完成后，8周 运动干预后。 这项研究将为您提供见解 用AA中的2型DM辅助的代谢异常和 对AA和CA人群进行运动干预的重要性。 这 本研究的结果可能是开处方的基础 AA 2型糖尿病患者的有效运动方式 Mellitus。 我相信我过去的经历使我为职业做好了准备 作为独立研究者的学术研究。 拟议的K08 格兰特将帮助我实现这些目标，并成为竞争力 用于公共卫生服务和其他国家资金。 这个项目是 我以前参与其中的研究的连续性 检查葡萄糖代谢的区域，很少知道， 运动对葡萄糖代谢的影响的种族差异。