NEUROENDOCRINOLOGY OF REPRODUCTIVE AGING

生殖衰老的神经内分泌学

基本信息

批准号：
6339527
负责人：
PULIYUR S MOHANKUMAR
金额：
$ 5.13万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-15 至 2002-02-28
项目状态：
已结题

项目摘要

The applications long-term objective is to investigate neurodocrine changes responses for age-related loss of reproduction. The specific aims of this application are to use the techniques of high performance liquid chromatography with electrochemical detection and radioimmunoassay to determine age related changes in the release of catecholamines, serotonin, and luteinizing hormone and prolactin. The data on the release of neurotransmitters will be correlated with changes in serum levels of luteinizing hormone and prolactin. Changes in these parameters will also be determined in old acyclic animals. Role of gamma amino butyric acid in aged-related changes in luteinizing in old acyclic animals. Role of gama amino butyric acid in age-related changes in luteinizing hormone secretion and its interaction with norepinephrine will be test in young and aging animals. Changes in the response of neurotransmitters to prolonged exposure to estradiol will be determined by monitoring neurotransmitter release in young cycling animals. Similarly, the involvement of catecholamines in progesterone-induced reinitiation of estrous cycles in middle -aged persistent estrus animals will be examined. Patterns of neurotransmitters and hormone release will also be determined in old animals after induction of estrous cyclicity. The data collected will explain the involvement of neurotransmitters in normal reproductive cycles and in-age related changes in cyclicity. These data will be new and will add to our knowledge of the neuroendocrine involvement in loss of reproductive cyclicity in aging.

应用长期目标是研究神经分泌变化与年龄相关的繁殖丧失的反应。本应用程序的具体目的是使用高技术具有电化学检测的性能液相色谱法和放射免疫分析，以确定与年龄相关的变化儿茶酚胺，5-羟色胺和黄体生成激素和催乳素。数据关于释放神经递质将与变化有关黄体生成激素和催乳素的血清水平。这些变化参数也将在旧的无环动物中确定。伽玛的角色氨基酸的氨基丁酸在老年相关的叶片变化中动物。 gama氨基丁酸在与年龄相关的变化中的作用黄体生成激素分泌及其与去甲肾上腺素的相互作用将在年轻动物和衰老的动物中进行测试。响应的变化神经递质长期暴露于雌二醇将由监测年轻骑自行车动物中的神经递质释放。相似地，儿茶酚胺参与孕激素引起的重新引入将检查中间持续性发情动物中的发情循环。还将确定神经递质和激素释放的模式在诱导发情环境后的老动物中。收集的数据将解释神经递质参与正常的生殖周期和与年龄相关的循环变化。这些数据将是新的，并且会增加我们对神经内分泌的了解参与衰老中生殖循环的丧失。

项目成果

期刊论文数量（23）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Interleukin-1 stimulates the release of dopamine and dihydroxyphenylacetic acid from the hypothalamus in vivo.

Interleukin-1 刺激体内下丘脑释放多巴胺和二羟基苯乙酸。

DOI：
10.1016/0024-3205(91)90040-i
发表时间：
1991
期刊：
Life sciences
影响因子：
6.1
作者：
Mohankumar,PS;Thyagarajan,S;Quadri,SK
通讯作者：
Quadri,SK

Neuroendocrine effects of perfluorooctane sulfonate in rats.

DOI：
10.1289/ehp.6128
发表时间：
2003-09
期刊：
ENVIRONMENTAL HEALTH PERSPECTIVES
影响因子：
10.4
作者：
Austin, Maureen E;Kasturi, Badrinarayanan S;Barber, Matthew;Kannan, Kurunthachalam;MohanKumar, Puliyur S;MohanKumar, Sheba M J
通讯作者：
MohanKumar, Sheba M J

Deprenyl reinitiates estrous cycles, reduces serum prolactin, and decreases the incidence of mammary and pituitary tumors in old acyclic rats.

Deprenyl 重新启动动情周期，降低血清催乳素，并降低老年无周期大鼠的乳腺和垂体肿瘤的发生率。

DOI：
10.1210/endo.136.3.7867565
发表时间：
1995
期刊：
Endocrinology.
影响因子：
0
作者：
Thyagarajan,S;Meites,J;Quadri,SK
通讯作者：
Quadri,SK

The estrous cycle affects pseudorabies virus (PRV) infection of the CNS.

发情周期影响中枢神经系统的伪狂犬病病毒（PRV）感染。

DOI：
10.1016/s0006-8993(00)03320-5
发表时间：
2001
期刊：
Brain research
影响因子：
2.9
作者：
Weiss,ML;Dobbs,ME;MohanKumar,PS;Chowdhury,SI;Sawrey,K;Guevara-Guzman,R;Huang,J
通讯作者：
Huang,J

Deprenyl stimulates the efflux of monoamines from the rat hypothalamus in vitro.

丙炔苯丙胺在体外刺激大鼠下丘脑的单胺流出。