COMPARATIVE PHYSIOLOGY OF SLEEP

睡眠的比较生理学

• 批准号: 2839368
• 负责人: JEROME M SIEGEL
• 金额: $ 13.94万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2839368
• 关键词: Chelonia; Mammalia; REM sleep; acetylcholine; brain electrical activity; brain mapping; brain regulatory center; brain stem; circadian rhythms; dorsal raphe nucleus; electrocardiography; electroencephalography; evolution; immunocytochemistry; lizards; locus coeruleus; neurotransmitter receptor; norepinephrine; serotonin; sleep; species difference; video recording system; wakefulness

DESCRIPTION (adapted from applicant's abstract): In the current grant period, these investigators have found that the platypus and echidna, primitive mammals previously thought to lack REM sleep, have REM sleep in very large amounts. This finding suggests that REM sleep may have evolved in the reptilian ancestors of mammals. Aminergic and cholinergic neurons have central roles in REM sleep control. Noradrenergic and serotonergic cells are tonically active during waking and reduce discharge rate in nonREM sleep. During REM sleep, and only during REM sleep, serotonergic and noradrenergic cell groups show a complete cessation of discharge in all mammals examined. A subpopulation of cholinergic cells is selectively active in REM sleep. Other cholinergic cells are active in both waking and REM sleep. Recent immunohistochemical work has established that these three cell groups exist in the reptile. These findings suggest that REM sleep or a precursor state should exist in reptiles. Observation of the discharge patterns of brainstem aminergic and cholinergic cell groups could determine the key neuronal characteristics of reptilian sleep. The investigators propose to conduct the first studies of brainstem monoaminergic and cholinergic cell discharge in non-mammalian species. They will use microwire techniques that allow long term recording in the freely moving animal. They will study the activity of noradrenergic, serotonergic and cholinergic cells during waking and sleep in two reptiles, the box turtle (Terrapene carolina) and the iguana (Iguana iguana). Study of the activity of aminergic and cholinergic cells in reptiles will provide critical data bearing on the evolution of: 1) REM and nonREM sleep states; 2) the waking discharge patterns of aminergic and cholinergic cells; 3) the receptors and membrane mechanisms governing discharge of these cells in mammals; and 3) the functional role of these cell types.

描述（根据申请人的摘要改编）：在当前赠款中 时期，这些研究人员发现鸭嘴兽和echidna， 原始哺乳动物以前被认为缺乏REM睡眠，雷姆睡觉 非常大的。 这一发现表明REM睡眠可能已经发展 在哺乳动物的爬行动物祖先中。 氨基和胆碱能神经元 在REM睡眠控制中具有中心作用。 去甲肾上腺素能和血清素能 细胞在醒来过程中具有音调活跃，并降低非REM的排放率 睡觉。 在REM睡眠期间，仅在REM睡眠期间，血清素能和 去甲肾上腺素能细胞组显示出所有的排放量 检查了哺乳动物。 胆碱能细胞的亚群是有选择的 活跃在REM睡眠中。 其他胆碱能细胞在醒来和 REM睡觉。 最近的免疫组织化学工作已经确定了这三个 细胞组存在于爬行动物中。 这些发现表明，REM睡眠或前体状态应存在 爬行动物。 观察脑干氨基化的排放模式和 胆碱能细胞组可以确定关键的神经元特征 爬行动物睡眠。 调查人员建议对 非哺乳动物的脑干单胺能和胆碱能细胞排放 物种。 他们将使用允许长期录制的微线技术 在自由移动的动物中。 他们将研究去甲肾上腺素的活性， 在两个爬行动物中醒来和睡觉时血清素能和胆碱能细胞， 盒龟（Terrapene carolina）和鬣蜥（鬣蜥鬣蜥）。 学习 爬行动物中氨基能和胆碱能细胞的活性将提供 关键数据涉及：1）REM和非REM睡眠状态； 2）氨基和胆碱能细胞的醒来排放模式； 3） 管理这些细胞排放的受体和膜机制 哺乳动物； 3）这些细胞类型的功能作用。

项目成果

Sleep in the platypus.

睡在鸭嘴兽里。

• DOI: 10.1016/s0306-4522(98)00588-0
• 发表时间: 1999
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Siegel,JM;Manger,PR;Nienhuis,R;Fahringer,HM;Shalita,T;Pettigrew,JD
• 通讯作者: Pettigrew,JD

State-related discharge of neurons in the brainstem of freely moving box turtles, Terrapene carolina major.

自由移动的闭壳龟（Terrapene carolina Major）脑干神经元的状态相关放电。

• 发表时间: 2001
• 期刊: Archives italiennes de biologie
• 影响因子: 1
• 作者: Eiland,MM;Lyamin,OI;Siegel,JM
• 通讯作者: Siegel,JM

Monotremes and the evolution of rapid eye movement sleep.

单孔目动物和快速眼动睡眠的进化。

• DOI: 10.1098/rstb.1998.0272
• 发表时间: 1998
• 期刊: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• 作者: Siegel,JM;Manger,PR;Nienhuis,R;Fahringer,HM;Pettigrew,JD
• 通讯作者: Pettigrew,JD

The echidna Tachyglossus aculeatus combines REM and non-REM aspects in a single sleep state: implications for the evolution of sleep.

针鼹 Tachyglossus aculeatus 在单一睡眠状态中结合了快速眼动和非快速眼动方面：对睡眠进化的影响。

• DOI: 10.1523/jneurosci.16-10-03500.1996
• 发表时间: 1996
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Siegel,JM;Manger,PR;Nienhuis,R;Fahringer,HM;Pettigrew,JD
• 通讯作者: Pettigrew,JD