GORDON CONFERENCE ON EXCITATION/CONTRACTION COUPLING

戈登兴奋/收缩耦合会议

• 批准号: 2082007
• 负责人: GERHARD W MEISSNER
• 金额: $ 1.45万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-01 至 1995-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2082007
• 关键词: calcium channel; calcium transporting ATPase; meeting /conference /symposium; muscle contraction; muscle function; travel

The proposed conference on Muscle:Excitation-Contraction (E-C) Coupling is scheduled for July 3-8,1994, at Tilton School, New Hampshire, under the sponsorship of the Gordon Research Conferences. The last conference on this subject was held in 1991. The timing of the current conference is particularly appropriate in view of the recent convergence of physiological, biophysical, and molecular biological approaches in determining the molecular properties of the components of E-C coupling, their assembly and regulation in muscle as well as nonmuscle tissues. Themes to be developed include the following: Ca2+ homeostasis and plasmalemmal ion permeability in normal muscle and muscle diseases; structure and regulatory mechanisms of the sarco/endoplasmic reticulum Ca2+ pump; structure and assembly of E-C coupling components; voltage control of Ca2+ release in skeletal muscle; regulation of Ca2+ release by putative endogenous Ca2+ mobilizing agents (Ca2+, lP3, cyclic ADP-ribose, etc.) in muscle and nonmuscle preparations; application of modern imaging techniques to the measurement of intracellular [Ca2+] in muscle and non muscle cells; and molecular approaches to studying structure-function relations of dihydropyridine, ryanodine and lP3 receptor/Ca2+ channels. Oral presentations of posters by young investigators will take place at the end of each session. The conference will be divided into nine sessions with scheduled session leaders, speakers and discussants, poster sessions and discussion time. The Gordon Conference's on E-C coupling have a highly successful history of bringing together active investigators from all over the world in a format which encourages free and informal exchange of ideas and unpublished data. The open discussion of ongoing work is valuable at this time in the E-C coupling field because recent advances have opened up new avenues of investigation. No other conference bringing together such a wide range of expertise in this area of research is planned in the near future.

拟议的肌肉：兴奋-收缩（E-C）耦合会议是 定于 1994 年 7 月 3 日至 8 日在新罕布什尔州蒂尔顿学校举行， 戈登研究会议的赞助。上次会议于 该主题于 1991 年举行。本次会议的时间是 鉴于最近的趋同，特别合适 生理学、生物物理学和分子生物学方法 确定E-C耦合组分的分子特性， 它们在肌肉和非肌肉组织中的组装和调节。 待开发的主题包括：Ca2+ 稳态和 正常肌肉和肌肉疾病中的质膜离子渗透性； 肌肉/内质网的结构和调节机制 钙泵； E-C耦合部件的结构和装配；电压 控制骨骼肌中 Ca2+ 的释放； Ca2+释放的调节 推定的内源性 Ca2+ 动员剂（Ca2+、LP3、环 ADP-核糖、 等）在肌肉和非肌肉制剂中；现代影像学的应用 测量肌肉和非细胞内 [Ca2+] 的技术 肌肉细胞；和研究结构功能的分子方法 二氢吡啶、兰尼碱与lP3受体/Ca2+通道的关系。 年轻研究人员对海报的口头展示将在 每节课结束时。 会议将分为九个分会场，并安排分会场 领导者、演讲者和讨论者、海报会议和讨论时间。 戈登会议在 E-C 耦合方面有着非常成功的历史 将来自世界各地的积极调查人员聚集在一起 鼓励自由和非正式的思想交流的格式 未发表的数据。对此，对正在进行的工作进行公开讨论很有价值 电-电耦合领域的时间，因为最近的进展开辟了新的领域 调查途径。没有其他会议能够汇集这样的 计划在不久的将来收集该研究领域的广泛专业知识 未来。