HOST TUMOR INTERACTION IN BURKITTS LYMPHOMA

伯基茨淋巴瘤中宿主肿瘤的相互作用

• 批准号: 2292080
• 负责人: G. J THORBECKE
• 金额: $ 3万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-01 至 1996-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2292080
• 关键词: African; Burkitt's lymphoma; CD antigens; Epstein Barr virus; SCID mouse; T cell receptor; T lymphocyte; apoptosis; clone cells; human subject; immunoglobulin isotypes; interleukin 2; molecular oncology

Our recent work on the SJL mouse model of follicular center B cell lymphoma (RCS) has established a strong link between the transcription of a novel endogenous mouse mammary tumor virus (MMTV) that serves as an indirect oncogen, mediating the vigorous superantigen-like stimulation of syngeneic CD4+Vbeta16+ T cells upon which RCS depend for their growth. RCS lymphomas share a number of salient features with Burkitt's lymphomas (BL). Both lymphomas are germinal center derived (both express the germinal center specific antigen, CD77); and like RCS lymphomas, BL tumors have T cell infiltrations that could have a potential role in the lymphomagenesis. The overall aim of this proposal is to utilize the findings in the RCS model as a basis for dissection of the role of host T cells in the development of BL. In view of the heterogeneous nature of BL tumors, we will examine a number of African BL tumors from various patients in Ghana (where BL is prevalent) in an attempt to relate tumor phenotypes to their stimulation of particular host T cell subpopulations and to their sensitivity to apoptosis.

我们最近对卵泡中心 B 细胞 SJL 小鼠模型的研究 淋巴瘤 (RCS) 的转录与 一种新型内源性小鼠乳腺肿瘤病毒（MMTV） 间接致癌物，介导强烈的超抗原样刺激 RCS 的生长依赖于同基因 CD4+Vbeta16+ T 细胞。 RCS 淋巴瘤与伯基特淋巴瘤有许多共同的显着特征 （BL）。 两种淋巴瘤均源自生发中心（均表达 生发中心特异性抗原，CD77)；和 RCS 淋巴瘤、BL 肿瘤一样 具有 T 细胞浸润，可能在 淋巴瘤发生。 该提案的总体目标是利用 RCS 模型中的发现作为剖析宿主 T 作用的基础 BL 发育中的细胞。 鉴于BL的异构性 肿瘤，我们将检查来自不同国家的一些非洲 BL 肿瘤 加纳（BL 盛行）的患者试图将肿瘤联系起来 表型对特定宿主 T 细胞亚群的刺激 以及它们对细胞凋亡的敏感性。