What shapes our brain?

是什么塑造了我们的大脑？

• 批准号: FT180100082
• 负责人: Prof Mary Tolcos
• 金额: $ 63.33万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-05-02 至 2024-05-02
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT180100082
• 关键词: What; shapes; our; brain

This project aims to improve our fundamental understanding of the biological mechanisms that drive folding of the cerebral cortex, which occurs during development of the brain. Cortical folding is unique to humans and higher mammals, and is thought to underpin the emergence of intelligence and contribute to higher-order brain functions. This project will enhance knowledge of how the cerebral cortex folds and develop novel tools for analysing brain development. The project will provide significant benefits including the generation of fundamental knowledge with implications for future understanding of cortical folding abnormalities in babies born preterm, following fetal growth retardation in utero, or when exposed to maternal alcohol. In the longer term, the project will contribute to improvements to human neurodevelopment and brain health.

该项目旨在提高我们对驱动大脑皮质折叠的生物学机制的基本理解，该机制发生在大脑的发育过程中。皮质折叠是人类和更高的哺乳动物所独有的，被认为是智力的出现并有助于高阶脑功能。该项目将增强有关大脑皮层如何折叠和开发用于分析大脑发育的新工具的知识。该项目将提供重大的好处，包括产生基本知识，对未来对婴儿早产的皮质折叠异常的了解，胎儿生长迟缓，或者在暴露于孕产妇酒精时。从长远来看，该项目将有助于改善人类神经发育和大脑健康。