TOXIC/CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS

选定化学品的有毒/致癌潜力

• 批准号: 6127611
• 负责人: J D PREJEAN
• 金额: $ 50.31万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 2000-04-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6127611
• 关键词: carcinogen testing; environmental toxicology; laboratory mouse; laboratory rat; nitrobenzene; organic chemicals; toluene; toxicant screening

The purpose of this project, entitled "Conduct of Studies to Evaluate the Toxicological and Carcinogenic Potential of Selected Chemicals - Riddelline, o-Nitrotoluene, m-Nitrotoluene, p-Nitrotoluene, 2,4- Decadienal, and 2,4-Hexadienal in Laboratory Animals", is to provide for the testing of these six chemicals for the NTP Program. The objective is to continue to characterize the toxicologic effects of chemical and physical substance through studies in animals. The typical approach is repeated administration of the agent to groups of animals for variable periods up to two years or more with clinical, toxicologic and pathologic evaluation of the adverse health effects by comparison with groups of control animals. The second phase of this contract, following the developmental efforts in the base contract, will involve the actual conduct of the prechronic and chronic toxicity/carcinogenicity studies.

该项目的目的，名为“研究的行为来评估 选定化学物质的毒理学和致癌潜力 - Riddelline，O-亚硝基苯甲苯，M-硝基苯甲苯，p-硝基苯二元，2,4-- 在实验动物中丧生和2,4-己二烯”将提供 对NTP程序的这六种化学物质的测试。目标是 继续表征化学和 通过在动物中研究的物质物质。典型的方法是 重复将试剂施用到动物组的可变 临床，毒理学和病理学最多两年或更长时间 通过与 控制动物。 在发展努力之后，本合同的第二阶段 在基本合同中，将涉及预总结的实际行为 和慢性毒性/致癌性研究。