OXYTOCIN, VASOPRESSIN AND DEVELOPMENT OF SOCIAL BEHAVIOR

催产素、加压素和社会行为的发展

• 批准号: 2861569
• 负责人: JAMES Timothy WINSLOW
• 金额: $ 23.51万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-10 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2861569
• 关键词: Macaca mulatta; arginine vasopressin; behavior test; behavioral /social science research tag; brain mapping; chronic disease /disorder; cognition disorders; disease /disorder model; gene expression; hormone receptor; hormone regulation /control mechanism; inhibitor /antagonist; neural information processing; neural transmission; neuropeptides; neuropharmacology; oxytocin; postmortem; psychological reinforcement; social behavior; social behavior disorders; vasopressins

Several recent studies have demonstrated that central oxytocin and vasopressin pathways are important for species typical social behaviors in rodents. This proposal extends this work to non-human primates by investigating oxytocin and vasopressin in both normal and socially abnormal rhesus monkeys. Proposed studies will characterize the social and cognitive deficits in these monkeys, investigate the influence of centrally administered agonists and antagonists, and in post-mortem studies, assess oxytocin and vasopressin function with cellular and molecular techniques. As many of the behavioral deficits in these socially abnormal monkeys resemble the core features of autism and the deficit syndrome of schizophrenia, and reactive attachment disorder, the results from the proposed studies may provide important insights about the pathophysiology and novel medications for these treatment-refractory syndromes.

最近的一些研究表明，中央催产素和 加压素途径对于物种典型的社会行为很重要 在啮齿动物中。 该建议将这项工作扩展到非人类灵长类动物 在正常和社会上研究催产素和加压素 异常的恒河猴。 拟议的研究将表征社会 和这些猴子的认知缺陷，研究 集中管理的激动剂和拮抗剂，并在验尸中 研究，评估催产素和加压素的功能 分子技术。 与这些行为缺陷一样 社会异常的猴子类似于自闭症的核心特征和 精神分裂症的赤字综合征和反应性依恋障碍， 拟议研究的结果可能会提供有关有关的重要见解 这些治疗难治性的病理生理学和新型药物 综合征。