BLOCKING IN ODOR MIXTURES

阻隔气味混合物

• 批准号: 6043338
• 负责人: JAY S HOSLER
• 金额: $ 4万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6043338
• 关键词: Hymenoptera; alternatives to animals in research; behavioral /social science research tag; biological models; chemical chain length; chemical group; chemical structure function; electrical measurement; ethology; interneurons; morphology; neural plasticity; odors; olfactions; olfactory stimulus; perceptual maskings; sensory mechanism

This proposal seeks to understand the way in which honeybees process components of an odorant blend. Behavioral studies of attention have made good use of a learning paradigm called "blocking" to study attention in non-human animals. As a model, the honeybee represents an invertebrate system that has been well studied. Several lines of experimental evidence indicate that blocking in bees occurs centrally rather than in the peripheral sensory cells of the antenna. As the first sensory processing center after the antenna, the antennal lobes may be the site at which synaptic plasticity leads to blocking. This work will focus on the antennal lobes. Recently, a model of the antennal lobe by Linster and Smith has been used to investigate the role of the antennal lobe central circuitry in extracting essential elements from odorant blends, initial behavioral experiments will establish standardized sensory input, the degree of generalization between odorants based on the two parameters chain-length and functional group and the degree of blocking between similar odorants. The behavioral experiments will lay the ground work for the subsequent physiological experiments. Changes in signalling in the antennal lobes before and after blocking will be measure using intracellular recording techniques from the interneurons and projections. The similarity in neural architecture between the insect antennal lobe and the vertebrate olfactory bulb may make the bee an excellent model for elucidating the phenomenon of attention.

该提议试图了解Honeybees流程的方式 气味混合物的组成部分。 注意力研究的行为研究 很好地利用了称为“阻止”学习的学习范式 非人类动物的注意。 作为模型，蜜蜂代表 已经经过深入研究的无脊椎动物系统。 几行 实验证据表明，蜜蜂中的阻塞发生在中央发生 而不是在天线的周围感觉细胞中。 作为第一个 天线之后的感觉处理中心，触角裂片可能是 突触可塑性导致阻塞的部位。 这项工作将 专注于触角裂片。 最近，触角叶的模型 林斯特和史密斯已被用来研究触角的作用 从气味中提取基本元素的叶中央电路 混合，初始行为实验将建立标准化的感觉 输入，基于两者的气味剂之间的概括程度 参数链长和功能组以及程度 在类似的气味剂之间阻塞。 行为实验将进行 随后的生理实验的地面工作。 更改 在阻塞之前和之后的触角裂片中的信号传导将是 使用中间神经元的细胞内记录技术测量 和预测。 神经建筑的相似性 昆虫触角叶和脊椎动物嗅球可能会使蜜蜂成为蜜蜂 阐明注意力现象的绝佳模型。