EXPERIENCE OF LUNG CANCER SURVIVORSHIP

肺癌幸存者的经历

• 批准号: 2694499
• 负责人: Linda P Sarna
• 金额: $ 10万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2694499
• 关键词: age difference; cancer registry /resource; chronic obstructive pulmonary disease; clinical research; gender difference; human subject; long term survivor; neoplasm /cancer epidemiology; nonsmall cell lung cancer; outcomes research; quality of life; smoking; tobacco abuse

DESCRIPTION: (Applicant's Description) The purpose of this study is to provide, for the first time, a database about long-term disease-free survivors of non-small cell lung cancer (NSCLC). This study will be conducted in two phases. Phase 1 describes the perceptions of physical, psychological, social, and existential dimensions of QOL of NSCLC survivors (n=300), determines the relationships among the four QOL dimensions, and explores significant sociodemographic lung cancer characteristics, personality, health status, and health behavior predictors of QOL. Four hypotheses will be tested: 1) lung cancer survivors who are non or former smokers will have significantly better QOL than lung cancer survivors who continue to smoke; 2) male survivors will have significantly different QOL than female survivors of lung cancer; 3) QOL will be significantly different by type of histology and extent of surgical resection; and 4) better pulmonary function will be significantly related to better QOL. Phase 2 compares the perceived QOL of NSCLC survivors to a cohort group with chronic pulmonary disease matched on age, gender, and smoking history from the Lung Health Study Group. A fifth hypothesis will be tested to determine whether survivors of lung cancer will have significantly better QOL than age, gender, and smoking history matched cohorts with chronic obstructive pulmonary disease.

描述：（申请人的描述） 这项研究的目的是首次提供数据库 关于非小细胞肺癌的长期无疾病幸存者 （NSCLC）。 这项研究将分为两个阶段。 第1阶段描述了 对身体，心理，社会和存在的维度的看法 NSCLC幸存者的QoL（n = 300）决定了 四个QOL尺寸，并探索重要的社会人口统计学肺癌 特征，个性，健康状况和健康行为预测因素 QoL。 将检验四个假设：1） 非吸烟者或以前的吸烟者的QOL明显优于肺癌 继续吸烟的幸存者； 2）男性幸存者将有明显的 与肺癌的女性幸存者不同的质量； 3）QOL将会 组织学类型和手术程度的显着差异很大 切除; 4）更好的肺功能将与 更好的QOL。 第2阶段将NSCLC幸存者的感知QoL与A进行了比较 慢性肺疾病的队列组与年龄，性别和 肺部健康研究小组的吸烟史。 第五个假设将 进行测试以确定肺癌的幸存者是否会有 质量比年龄，性别和吸烟史相匹配的QOL要好得多 与慢性阻塞性肺部疾病的队列。