DCC: NATIONAL COOP INNER-CITY ASTHMA STUDY

DCC：国家合作内城哮喘研究

• 批准号: 2809946
• 负责人: Janet T. Wittes
• 金额: --
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-05 至 1998-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2809946
• 关键词: Alphaherpesvirinae; Betaherpesvirinae; antiviral agents; disease /disorder model; drug adverse effect; drug screening /evaluation; epidemiology; guinea pigs; information systems; tissue /cell culture; varicella zoster virus; virus diseases

The contractor will evaluate the clinical, virologic and toxicologic effects of putative antiviral agents directed at the management of herpes simplex viruses (HSV) types 1 and 2, cytomegalovirus (CMV) and varicella zoster virus (VZV). They will utilize guinea pig model systems because these models exhibit pathophysiological features analogous to the corresponding infection in humans. Human strains of HSV and VZV will be utilized; however, they will employ guinea pig CMV since it is not possible to infect guinea pigs with human CMV. The contractor will first test the candidate compounds for in vitro activity in fetal guinea pig cells against the test virus strain intended for animal inoculation. They will explore for potential drug toxicity in the animal model system. They will then evaluate the experimental therapeutic agents as potential drugs for the treatment of varicella, primary and recurrent genital herpes, neonatal herpes, and cytomegalovirus infections exploring for drug efficacy, toxicity and changes in the pathophysiology of infection. In addition to these studies, they will further refine their recently described guinea pig model of neonatal HSV infection to determine the usefulness of this experimental system to predict neurologic outcome of infection and treatment.

承包商将评估临床、病毒学和毒理学 假定的抗病毒药物治疗疱疹的效果 单纯病毒 (HSV) 1 型和 2 型、巨细胞病毒 (CMV) 和水痘 带状疱疹病毒（VZV）。 他们将利用豚鼠模型系统，因为 这些模型表现出类似于 人类相应的感染。 HSV 和 VZV 人类毒株将 已利用；然而，他们将使用豚鼠 CMV，因为这是不可能的 用人类 CMV 感染豚鼠。 承包商将首先测试 在豚鼠胎儿细胞中具有体外活性的候选化合物 用于动物接种的测试病毒株。 他们将探索 动物模型系统中潜在的药物毒性。 他们随后将 评估实验治疗剂作为潜在药物 治疗水痘、原发性和复发性生殖器疱疹、新生儿 疱疹和巨细胞病毒感染探索药物疗效， 毒性和感染病理生理学的变化。 此外 这些研究，他们将进一步完善他们最近描述的豚鼠 新生儿 HSV 感染模型以确定该方法的有效性 预测感染的神经系统结果的实验​​系统 治疗。