BRAIN IMAGING OF DEVELOPMENTAL LEARNING EFFECTS

发展性学习效应的脑成像

• 批准号: 2890041
• 负责人: HEMANTH P NAIR
• 金额: $ 2.1万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2890041
• 关键词: age difference; autoradiography; behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; brain mapping; brain metabolism; computational neuroscience; deoxyglucose; developmental neurobiology; developmental psychology; glucose metabolism; immature animal; laboratory rat; learning; reinforcer

DESCRIPTION (Adapted from applicant's abstract): The aim of the proposed research is to combine brain metabolic mapping and structural equation modeling, a statistical path analysis technique, to study postnatal maturation of the functional interactions of neural systems related to reinforcement, memory, and behavioral inhibition in the preweanling rat. In the proposed experiment, preweanling pups at 16-17 and 11-12 days of age will be trained, in a straight alley runway, on two reward schedules, patterned single alternation (PSA) and random partial reinforcement (PRF). Following training on these schedules, animals will be injected with fluorodeoexyglucose (FDG), a radio labeled glucose analog and then given 50 trials of extinction training, i.e. continuous non-reward. Immediately following training, they will be sacrificed and their brains processed for FDG. Glucose utilization in a number of brain regions will be quantified using image analysis sofware. Structural equation modeling will be applied to these data to quantify functional influences between anatomically connected brain regions. The network models derived from this process from PSA and PRF groups at each age will be compared. PSA and PRF comparisons in the 16-17 day old age group should reveal functional differences in the coordinated function of brain regions between animals demonstrating behavioral inhibition and perserveration, respectively. Comparison of 16-17 day old PSA and PRF groups to their 11-12 day old counterparts should reveal ontogenetic differences in brain activity related to the behavioral differences across the two ages. Handled controls will be included to control for brain activation related to handling and not learning per se. The major goal of this work is to contribute substantially to the understanding of metabolic maturation of brain regions related to reinforcement, memory, and behavioral inhibition, and how changes in their coordinated activity during postnatal development are reflected in behavior.

描述（改编自申请人的摘要）：拟议的目的 研究是结合大脑代谢映射和结构方程 建模，一种统计路径分析技术，用于研究产后 与之相关的神经系统功能相互作用的成熟 预断层大鼠的增强，记忆和行为抑制。 在 拟议的实验是16-17和11-12天的预断层幼崽 将在一条直线跑道上接受两个奖励时间表的训练， 图案化的单个交替（PSA）和随机部分加固（PRF）。 在对这些时间表进行培训后，将注射动物 氟二糖果糖（FDG），一个无线电标记的葡萄糖类似物，然后给出50 灭绝训练的试验，即连续不回报。 立即地 训练后，他们将被牺牲，并处理其大脑 FDG。 许多大脑区域中的葡萄糖利用率将被量化 使用图像分析SOFWARE。 将应用结构方程建模 这些数据以量化解剖学之间的功能影响 连接的大脑区域。 从此过程得出的网络模型 将比较每个年龄段的PSA和PRF组。 PSA和PRF比较 16-17天的年龄组应揭示 动物之间大脑区域的协调功能证明 行为抑制和持久性。 比较16-17 年龄大的PSA和PRF小组到他们11-12天大的同行应揭示 与行为相关的大脑活动的个体发育差异 两个年龄段的差异。 处理的控件将包括在内 控制大脑激活与处理相关的，而不是学习本身。 这项工作的主要目标是为 了解与大脑区域的代谢成熟 强化，记忆和行为抑制，以及如何改变其 产后发展期间的协调活动反映在行为中。