ANTECEDENTS OF PEAK BONE MASS IN BLACK & WHITE WOMEN

黑色峰值骨量的前因

• 批准号: 2766683
• 负责人: SUE Y.S. KIMM
• 金额: $ 23.14万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-18 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2766683
• 关键词: African American; biomarker; body composition; body physical activity; bone density; bone metabolism; calcium metabolism; caucasian American; collagen; diet; dietary calcium; female; gene environment interaction; gene expression; genetic mapping; human puberty; human subject; longitudinal human study; nutrition related tag; osteocalcin; physiologic bone resorption; racial /ethnic difference; vitamin D

The aim of this study is to investigate environmental, biologic, and genetic determinants of bone mass in a large (n=650) biracial of young women enrolled in the NHLBI Growth and Health Study. Eleven-year longitudinal data are available data are available on dietary intake, physical activity, body composition, pubertal milestones, pregnancy, oral contraceptive use, smoking, and alcohol intake. This cohort is also concurrently enrolled in a second study which obtains annual total body DEXA scans until year 2000. Nested within this study, we will 1) determine what environmental (current and antecedent) and genetic factors determine bone mass (BMD) at the lumbar spine and proximal femur at ages 20-22 years; 2) determine racial difference in the effects of the significant environmental and genetic factors found in aim #1; and 3) determine what environmental and genetic factors influence biochemical markers of bone metabolism and calcium homeostasis. Bone mass will be assessed several different ways in part to address the biethnic nature of the population. Genotyping will be done for variation at genetic loci intimately involved in bone metabolism and calcium homeostasis. Biomarkers include serum osteocalcin and ionized calcium, intact parathyroid hormone, and urinary N-telopeptides and calcium. The main hypotheses involve the effects of dietary calcium, vitamin D, physical activity, and pubertal maturation on BMD, and their interaction with each other as well as with genotypes. Attention will be directed to understanding the extent to which selected environmental and genetic factors influence the well-recognized black-white differences in BMD. The relative importance of the timing of "exposure" to these environmental factors will be assessed by analyzing data in biologically meaningful time periods defined by pubertal milestones. This study will provide a comprehensive evaluation of the role of an exhaustive set of environmental measures, genotypes, and biomarkers of bone/calcium homeostasis in determining BMD as well as in determining the racial differences in BMD. Thus, by capitalizing on the efficiency and cost- saving afforded by the two ongoing studies at Cincinnati Children's Hospital, our study can "telescope" the 11 years of follow-up to uncover important childhood antecedents of peak bone mass in black and white women.

这项研究的目的是研究环境，生物学和 大的（n = 650）幼小的骨量的遗传决定因素 妇女参加了NHLBI增长和健康研究。十一年 纵向数据可用，可用于饮食摄入量， 体育锻炼，身体成分，青春期里程碑，怀孕， 口服避孕药，吸烟和酒精摄入量。这个队列也是 同时参加第二项研究，该研究获得了年度总体 DEXA扫描到2000年。在这项研究中嵌套，我们将1） 确定哪些环境（当前和先行）和遗传 因素决定腰椎和股骨近端的骨骼质量（BMD） 年龄在20-22岁时； 2）确定种族差异 AIM＃1中发现的重要环境和遗传因素；和 3）确定哪些环境和遗传因素影响 骨代谢和钙稳态的生化标志物。骨 质量将被评估几种不同的方式来解决 人口的生物种族性质。基因分型将用于变异 在遗传基因座密切参与骨代谢和钙 稳态。生物标志物包括血清骨钙素和电离钙， 完整的甲状旁腺激素以及尿液N-甲基肽和钙。这 主要假设涉及饮食钙，维生素D的影响 体育锻炼和BMD上的青春期成熟及其相互作用 彼此以及基因型。注意将被关注 了解选择的环境和遗传的程度 因素会影响BMD中良好认可的黑白差异。 “暴露”对这些时机的相对重要性 环境因素将通过分析生物学的数据来评估 有意义的时期由青春期的里程碑定义。这项研究会 对一组详尽的作用进行全面评估 骨/钙的环境测量，基因型和生物标志物 确定BMD以及确定种族的稳态 BMD的差异。因此，通过利用效率和成本 - 辛辛那提儿童正在进行的两项研究所提供的储蓄 医院，我们的研究可以“望远镜”进行11年的随访，以发现 黑色和白色的重要童年骨骼质量的前身 女性。