USE OF BIOMARKERS TO MOTIVATE SMOKING CESSATION

使用生物标志物促进戒烟

• 批准号: 6103284
• 负责人: COLLEEN M MC BRIDE
• 金额: --
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6103284
• 关键词: African American; behavior modification; behavioral /social science research tag; biomarker; bleomycin; cancer prevention; cancer risk; carbon monoxide; clinical research; community health services; counseling; genetic counseling; genetic markers; genotype; health care cost /financing; human genetic material tag; human subject; human therapy evaluation; longitudinal human study; lung neoplasms; motivation; neoplasm /cancer education; self help; smoking cessation; tobacco abuse education

African Americans, particularly men, have high rates of smoking and concomitantly high rates of smoking-related cancers. Recent developments in the identification of genetic markers of susceptibility to tobacco related cancers provide exciting opportunities for developing innovative health education strategies that personalize risk and enhance motivation for smoking cessation. The proposed study is a five year randomized trial to evaluate the incremental improvement of providing biomarker feedback to state-of-the-science smoking cessation interventions to increase motivation and likelihood of cessation among African American smokers. Three intervention conditions will be tested in an additive study design. Patients who receive care at a community health clinic that serves a predominantly African American population will be screened for smoking status in the waiting rooms to identify current smokers. Smokers who agree to provide a breath and blood sample and take part in the smoking cessation intervention (n=620) will be randomized t one of three intervention conditions (1) Self-help guide plus motivational telephone counseling (Enhanced al care, n-160); (2) Self-help guide plus motivational tailored feedback that includes expired carbon monoxide (CO) results plus motivational telephone counseling (Exposure biomarker feedback, n=160); (3) Self-help guide plus tailored feedback that includes test results for CO and the presence of genetic biomarkers of susceptibility to lung cancer plus motivational telephone counseling (Susceptibility biomarker feedback, n-300). Data collection will include an in-person baseline survey, telephone follow-up surveys at 6,12, and 18 months, and collection of saliva samples to validate self-reported abstinence. The primary outcomes of interest will be motivation to quit smoking, point prevalence, and sustained abstinence at each follow-up. The proposed study is integrally linked to the overall project theme, "Improving Cancer Risk Communications." The framework for the CPRU enables us to assemble a multidisciplinary team that brings the best and brightest together to develop our communication approaches. The economics of scale inherent in the CPRU Cores will permit us to include cost effectiveness analysis and a solid biostatistical resource at modest cost.

非裔美国人，尤其是男性，吸烟率很高 与吸烟相关的癌症的发病率也很高。最新动态 烟草易感性遗传标记的鉴定 相关癌症为开发创新提供了令人兴奋的机会 个性化风险并增强动力的健康教育策略 用于戒烟。拟议的研究是一项为期五年的随机试验 评估提供生物标志物反馈的增量改进 采用最科学的戒烟干预措施，以增加 非裔美国吸烟者戒烟的动机和可能性。 将在附加研究设计中测试三种干预条件。 在社区卫生诊所接受护理的患者 主要是非洲裔美国人将接受吸烟筛查 候诊室的状态以识别当前吸烟者。吸烟者 同意提供呼吸和血液样本并参与吸烟 戒烟干预 (n=620) 将被随机分配到以下三者之一 干预条件（一）自助引导加励志电话 咨询（加强护理，n-160）； （2）自助引导加 激励性定制反馈，包括过期一氧化碳 (CO) 结果加上动机电话咨询（暴露生物标志物 反馈，n=160）； (3) 自助指南加上量身定制的反馈 包括 CO 检测结果以及遗传生物标志物的存在 肺癌易感性加励志电话咨询 （易感性生物标志物反馈，n-300）。 数据收集将包括 现场基线调查、6,12 电话跟踪调查，以及 18个月，收集唾液样本以验证自我报告 节制。兴趣的主要结果将是戒烟的动机 每次随访时吸烟情况、患病率和持续戒烟情况。 拟议的研究与整个项目主题密切相关， “改善癌症风险沟通。” CPRU 的框架 使我们能够组建一支多学科团队，带来最好的和 最聪明的人一起开发我们的沟通方法。经济学 CPRU 内核固有的规模将使我们能够将成本包括在内 有效性分析和可靠的生物统计资源 成本。