CERAMIC TIBIA FOR MOBILE BEARING KNEE

移动轴承膝关节用陶瓷胫骨

• 批准号: 6016906
• 负责人: ASHOK C KHANDKAR
• 金额: $ 9.88万
• 依托单位: SINTX TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-29 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6016906
• 关键词: biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biomechanics; ceramics; cerium; composite resins; implant; joint prosthesis; knee; mechanical stress; medical implant science; scanning electron microscopy; skeletal stress; tibia; tissue engineering; yttrium; zirconium

Recent developments and experience in aerospace/engineering applications has established a clear superiority of layered composite zirconia/steel couples as ultra low wear. This has a great potential for implant applications in virtually eliminating wear particle mediated osteolysis and consequent implant failures. Wear rates comparable to ceramic/ceramic couples with demonstrated 2-3 orders lower wear volume than the best ceramic/PE couples can be expected. In contrast to the ceramic/ceramic couples however, the proposed composite ceramic/metal couple alleviates the major clinical concern stemming from brittle fracture. In a novel alternative approach to eliminating PE wear debris and lowering risk of brittle failure, a composite ceramic tibial component articulating against a Co-Cr femoral component is proposed. Developments and experience from the engineering fields is proposed to be applied to biomedical implant applications and is expected to lead to both superior wear resistance (comparable to the best ceramic/ceramic couples), with elimination of the PE tibial component. Toughness, enhancement of 2x over conventional ceramics significantly reduces risk of tibial failure. This is particularly relevant to mobile wearing knee designs where increased range of motion and resultant wear is observed. Phase 1 will establish the superior materials properties and demonstrate significantly reduced wear rates. In Phase 2, wear simulator tests will be conducted along with design and manufacturing process optimization. PROPOSED COMMERCIAL APPLICATION The novel combination of an ultra-tough composite ceramic tibial components articulating against Co-Cr femoral components will lead to negligible wear debris and implant failures. Adaptation and enhancement of an established engineering ceramic for articulation with the established Co-Cr condylar components will greatly enhance commercial applications.

航空/工程应用方面的最新发展和经验已确立了分层复合氧化锆/钢夫妇的明显优势，因为超低磨损。 这具有植入物在实际上消除磨损颗粒介导的骨溶解以及随之而来的植入物失败方面具有巨大潜力。 与最佳陶瓷/PE夫妇相比，磨损速度与陶瓷/陶瓷夫妇的磨损量低于2-3个订单。 但是，与陶瓷/陶瓷夫妇相反，提议的复合陶瓷/金属夫妇减轻了脆性骨折引起的主要临床关注。 在消除PE磨损碎屑和降低脆性衰竭风险的一种新型替代方法中，提出了一种针对Co-Cr股骨成分的复合陶瓷胫骨成分。 提议从工程领域的发展和经验应用于生物医学植入物应用，并有望导致出色的耐磨性（与最佳的陶瓷/陶瓷夫妇相当），并消除了胫骨成分。 韧性，增强2倍对传统陶瓷的增强可显着降低胫骨衰竭的风险。 这与移动型膝盖设计特别相关，在观察到运动范围和导致磨损范围的增加。 第1阶段将建立出色的材料特性，并显示出显着降低的磨损率。 在第2阶段，将与设计和制造过程优化一起进行磨损模拟器测试。拟议的商业应用程序的新型组合，即针对Co-Cr股骨成分表达的超阻形陶瓷胫骨成分将导致可忽略不计的磨损碎片和植入物故障。 适应和增强已建立的工程陶瓷，以与已建立的Co-Cr Condylar组件发音，将大大增强商业应用。