STRESS, ESTROGEN, OPIOIDS AND ATHEROGENESIS IN WOMEN

女性的压力、雌激素、阿片类药物和动脉粥样硬化

• 批准号: 6281822
• 负责人: JAMES A MCCUBBIN
• 金额: $ 3.06万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281822
• 关键词: cardiovascular function; clinical research; endogenous opioid; estrogens; female; hormone therapy; human subject; human therapy evaluation; naltrexone; neuroendocrine system; postmenopause; progesterone; stress

To evaluate the effects of estrogen replacement therapy and estrogen replacement with progesterone on cardiovascular and neuroendocrine stress reactivity in post menopausal women. To compare the effects of the opioid antagonist naltrexone on cardiovascular stress reactivity in postmenopausal women taking estrogen replacement therapy, taking estrogen replacement plus progestin, and taking placebo therapy.

评估雌激素替代疗法和雌激素的影响 在心血管和神经内分泌压力上替代孕酮 绝经后妇女的反应性。 比较阿片类药物的作用 拮抗剂纳曲酮在心血管应激反应性上 绝经后妇女接受雌激素替代疗法，服用雌激素 替代加孕激素，并进行安慰剂疗法。