REGULATION OF HISTIDINE BIOSYNTHESIS IN YEAST

酵母中组氨酸生物合成的调控

• 批准号: 2608836
• 负责人: GERALD R FINK
• 金额: $ 42万
• 依托单位: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2608836
• 关键词: Candida; Saccharomyces cerevisiae; aminoacid biosynthesis; cell cycle; enzyme substrate complex; fungal genetics; gene expression; genetic mapping; genetic promoter element; genetic recombination; genetic regulation; genetic transcription; histidine; meiosis; molecular cloning; molecular genetics; mutagen testing; nucleic acid hybridization; nucleic acid sequence; posttranslational modifications; protein structure function; site directed mutagenesis

DESCRIPTION: This represents a far ranging proposal to explore molecular mechanisms of regulation in yeast by one of the founders of yeast molecular biology. The four tangentially related objectives are: 1) post- translational control of the S. cerevisiae GCN4 gene; 2) regulation of intracellular levels of amino acids, particularly histidine, in S. cerevisiae; 3) probing for existencing of a multicopy silencing system in S. cerevisiae; and 4) testing for evidence of a meiotic cycle in C. albicans.

描述：这代表了探索分子的一个远程提议 酵母创始人之一，酵母中调节的机制 分子生物学。 四个切向相关的目标是：1） 酿酒酵母GCN4基因的翻译后控制； 2） 调节细胞内水平的氨基酸，特别是 组氨酸，在酿酒酵母中； 3）探测存在多拷贝 酿酒酵母中的沉默系统； 4）测试证据 白色念珠菌中的减数分裂周期。