LAPAROSCOPIC ENTEROCYSTOPLASTY WITH LASER WELDING

激光焊接腹腔镜肠囊成形术

• 批准号: 2770523
• 负责人: ROBERT B STEWART
• 金额: $ 37.85万
• 依托单位: ABIOMED, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2770523
• 关键词: biomedical equipment development; dogs; endoscopy; female; laser therapy; lasers; method development; nonhuman therapy evaluation; urinary tract disorder

The objective of ther research in this proposal is to develop instrumentation and techniques to facilitate tissue approximation and repair in minimally invasive surgical (MIS) procedures where current methods of wound closure are either extremely difficult, such as suturing, or contraindicated, such as staples in vascular or urological reconstructions, The primary emphasis is on developing a laparoscopic device, which can be used to complete laser assisted repairs (tissue welding) or urologic structures. An enterocystoplasty is chosen because in its current suture intensive form, a conversion to a MIS procedure is unlikely. A programmatic approach has been chosen for this research program. Three major factors influencing tissue welded repairs 1) tissue absorption, 2) the temperature achieved during welding, 3) the use of tissue solders, were evaluated for acute repairs in Phase I. the Phase II studies will initially evaluate the chronic healing of laser assisted repairs. A laparoscopic instrument will also be constructed in Phase II to convert the enterocystoplasty to a MIS procedure. the instrumentation and methods developed ere should also have broad applicability to other urological reconstructions. PROPOSED COMMERCIAL APPLICATIONS: The laparoscopic instrument will be directly applicable to urologic reconstructions currently being completed via open procedures. These include enterocystoplasty, gastrocystoplasty, pyeloplasty, and reimplantation of the ureters. there are approximately 20,000 of these cases completed annually by the 6,500 practicing urologists in the US. In addition, other surgical procedures requiring minimally invasive tissue reconstruction and repair may also be candidates for this repair technology.

在此提案中进行研究的目的是发展 仪器和促进组织近似的技术 并维修微创手术（MIS）程序 当前的伤口闭合方法要么非常困难， 例如缝合或禁忌，例如血管中的主食或 泌尿外科重建，主要重点是发展 腹腔镜装置，可用于完成激光器 辅助维修（组织焊接）或泌尿科结构。 一个 之所以选择肠囊肿成形术，是因为目前的缝合线密集型 形式，转换为MIS过程的不太可能是不可能的。 为这项研究选择了一种程序化方法 程序。 影响组织焊接维修的三个主要因素1） 组织吸收，2）焊接过程中达到的温度，3） 使用组织焊料的使用，以相相评估急性维修 I. II期研究最初将评估 激光辅助维修。 腹腔镜仪器也将是 在第二阶段中构建以将肠胃成形术转换为MIS 程序。 开发的仪器和方法应该 还对其他泌尿外科重建也有广泛的适用性。 拟议的商业应用：腹腔镜 仪器将直接适用于泌尿科重建 目前正在通过公开程序完成。 这些包括 肠囊泡成形术，胃囊泡成形术，肾上腺成形术和 输尿管的再植入。 大约有20,000 这些案件每年由6,500名执业泌尿科医生完成 在美国。 此外，其他需要的手术程序需要 微创组织的重建和修复也可能是 该维修技术的候选人。