STRESS RESPONSIVENESS IN ABNORMAL REPETITIVE BEHAVIOR

异常重复行为中的应激反应

• 批准号: 2709742
• 负责人: Susan B Powell
• 金额: $ 1.7万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-24 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2709742
• 关键词: behavior disorders; behavioral /social science research tag; corticosteroid receptors; developmental psychology; dopamine; dopamine transporter; environmental stressor; glucocorticoids; hypothalamic pituitary adrenal axis; instinct; laboratory mouse; mother child interaction; mother deprivation; neuroendocrine system; psychological stressor; stress

DESCRIPTION: The current training proposal is part of a larger project investigating the development and neurobiological basis of spontaneous stereotyped behaviors in deer mice. This work represents an animal model of Stereotypic Movement Disorder and thus will be a close complement to our studies of stereotypy and related repetitive behavior disorders in individuals with developmental disabilities. Stress has been assumed to play an important role in the pathogenesis and expression of abnormal repetitive behaviors in various clinical populations as well as animals reared or housed in adverse environmental circumstances. Unfortunately, few data are available to test such an assumption. Thus, the present project will test directly the role of stress in the pathogenesis and expression of stereotyped behavior. The first approach to this problem will be to assess the effect of increased stress responsiveness on the development of spontaneous stereotypy in deer mice. This involves increasing the stress responsiveness of deer mice through extended maternal separation and assessing the development of stereotyped behavior. The second aim is to assess indices of stress responsiveness in stereotypic and non-stereotypic deer mice. This aim involves assessing stress-induced alterations in HPA axis and dopamine function in both stereotypic and non-stereotypic mice. In order to understand more fully the role that glucocorticoid and dopamine function play in the pathophysiology of stereotypy, glucocorticoid receptor mRNA expression in hippocampus and dopamine transporter densities in dopamine terminal fields will also be compared in stereotypic and non-stereotypic deer mice

描述：当前的培训提案是一个更大项目的一部分 研究自发性的发展和神经生物学基础 鹿鼠的刻板行为。 这项工作代表了一个动物模型 因此，刻板运动障碍将是我们的密切补充 刻板印象和相关重复行为障碍的研究 有发育障碍的人。 压力被假设为 在异常的发病机制和表达中起重要作用 各种临床人群以及动物的重复行为 在不利的环境条件下饲养或饲养。 不幸的是，很少有 有数据可以检验这样的假设。 因此，本项目 将直接测试应激在发病机制和表达中的作用 刻板的行为。 解决这个问题的第一个方法是评估 应激反应能力的增强对发育的影响 鹿小鼠的自发刻板印象。 这涉及增加压力 鹿鼠通过延长母体分离而做出的反应 评估定型行为的发展。 第二个目标是 评估刻板和非刻板的压力反应指数 鹿鼠。 该目标涉及评估压力引起的 HPA 变化 定型和非定型小鼠的轴和多巴胺功能。 在 为了更全面地了解糖皮质激素和多巴胺的作用 刻板病理生理学中的功能，糖皮质激素受体 海马 mRNA 表达和多巴胺转运蛋白密度 多巴胺末端场也将在刻板印象和 非定型鹿鼠