RESPONSE MODE DURING THALAMIC VISUAL PROCESSING

丘脑视觉处理期间的响应模式

• 批准号: 2708531
• 负责人: Gregory Douglas Smith
• 金额: $ 1.61万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2708531
• 关键词: action potentials; cats; computational neuroscience; lateral geniculate body; neural information processing; neural transmission; neurophysiology; thalamus; visual pathways

The goal of this project is to develop a realistic conductance-based network model of retinogeniculate transmission by the dorsal lateral geniculate nucleus (dLGN) and perigeniculate nucleus (PGN) of the cat. Previous theoretical work by my sponsor, John Rinzel (Center for Neural Science and Courant Institute for Mathematical Sciences, NYU) has elucidated the role of the low-threshold Ca2+ conductance (IT), GABA- ergic inhibition, and the post-inhibitory rebound (PIR) properties of thalamocortical (TC) and nuclear reticularis thalami (RE) neurons in the generation of rhythmic bursts of action potentials (APs) and the lurching propagation of spindle waves in the "sleeping" thalamic slice preparation. We will wake up" this thalamic slice model by tuning a parameter representing cholinergic neuromodulation and test two specific hypotheses regarding sensory gating by dLGN: 1) that transient bursts of APs fired by TC neurons can be stimulus driven and signal novelty detection in addition to functional disconnect of the thalamic gate, and 2) that control of local inhibitory RE neuron responsiveness can have functional consequences on the receptive field properties of TC neurons and, consequently, the filter properties of the dLGN. Predictions of the model will be tested in the laboratory of vision researcher S. Murray Sherman (SUNY, Stony Brook).

该项目的目的是开发基于逼真的电导 背面侧向传播的网络模型 猫的基因核（DLGN）和核核核（PGN）。 我的赞助商约翰·林泽尔（John Rinzel）（神经中心）以前的理论工作 科学与库兰特数学科学研究所，纽约大学） 阐明了低阈值Ca2+电导（IT），GABA-的作用 ERGIC抑制作用和抑制后反弹（PIR）特性 丘脑皮质（TC）和核网状丘脑（RE）神经元 产生节奏的动作电位（AP）和 在“睡觉”丘脑切片中徘徊的主轴波的传播 准备。 我们将通过调整一个 代表胆碱能神经调节并测试两个特定的参数 关于DLGN的感官门控的假设：1）瞬时爆发 TC神经元发射的AP可以是刺激驱动的，并信号是新颖的 除了丘脑门的功能断开外，还检测到 2）控制局部抑制性神经元反应能力可以具有 对TC神经元的接收场特性的功能后果 因此，DLGN的滤波器特性。预测 模型将在视觉研究员S. Murray实验室中进行测试 谢尔曼（纽约州立大学，斯托尼·布鲁克）。