AGE RELATED CARDIAC SENSITIVITY TO VOLATILE ANESTHETICS

与年龄相关的心脏对挥发性麻醉剂的敏感性

• 批准号: 2668540
• 负责人: Y. S. Prakash
• 金额: $ 17.54万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2668540
• 关键词: age difference; anesthesia complication; anesthetics; calcium channel; calcium flux; confocal scanning microscopy; drug adverse effect; heart disorder; heart function; laboratory rat; mature animal; muscle function; myocardium; newborn animals

DESCRIPTION: Cardiac depression is more pronounced in the neonatal heart than in the adult organ. The studies described in this project are designed to achieve the overall goal of identifying the mechanism underlying age-related (neonate versus adult) differences in the cardiac depressant effects of volatile anesthetics. This proposal addresses two of the three possible factors altering cardiac function: intracellular calcium and the sensitivity of the contractile apparatus to intracellular calcium. Using an adult versus neonatal rat model, the mechanisms underlying the effect of volatile anesthetics on 1) intracellular calcium regulation related specifically to influx through the L-type channel sand calcium release from the sarcoplasmic reticulum, and 2) Ca-sensitivity of force generation will be addressed, with the underlying hypothesis that both factors contribute to cardiodepression secondary to volatile anesthetics.

描述：心脏抑制在新生儿心脏中更为明显 比成人器官。该项目中描述的研究是 旨在实现确定机制的总体目标 心脏功能与年龄相关（新生儿与成人）的潜在差异 挥发性麻醉剂的抑制作用。该提案涉及其中两个 改变心脏功能的三个可能因素：细胞内 钙和收缩装置对细胞内的敏感性 钙。使用成年大鼠与新生大鼠模型，机制 挥发性麻醉剂对 1) 细胞内钙的影响 与通过 L 型河道沙子流入相关的特定调节 肌浆网中的钙释放，以及 2) 的钙敏感性 将解决力的产生问题，其基本假设是 这两个因素都会导致继发于挥发性心脏病的心脏抑制 麻醉剂。