RISKS AND BENEFITS OF MODERATE ALCOHOL

适量饮酒的风险和好处

• 批准号: 2769195
• 负责人: Carol A. Shively
• 金额: $ 25.49万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769195
• 关键词: Macaca fascicularis; aggression; alcoholic beverage consumption; atherosclerosis; atherosclerotic plaque; biological models; bone density; bone metabolism; breast neoplasms; cancer risk; cardiovascular pharmacology; dietary lipid; disease /disorder proneness /risk; estradiol; female; hormone regulation /control mechanism; immunocytochemistry; lipid metabolism; longitudinal animal study; nutrition related tag; osteoporosis; ovariectomy; postmortem; preneoplastic state; psychological stressor; skeletal pharmacology

APPLICANT'S ABSTRACT: While the deleterious effects of excessive alcohol consumption are well recognized, the effects of moderate alcohol consumption are not well understood. Currently, it is thought that moderate alcohol consumption reduces the risk of coronary heart disease (CHD), increases bone density, is anxiolytic, and promotes social interaction. Thus, there currently appears to be some benefit to moderate alcohol consumption. More worrisome is the possibility that moderate alcohol consumption may increase breast cancer risk, and that it may also lead to excessive alcohol consumption. Hence, there may be a risk/benefit trade-off to moderate alcohol consumption. We propose to assess the effects of moderate alcohol consumption on CHD, osteoporosis, and breast cancer risk in ovariectomized female cynomolgus monkeys (Macaca fascicularis), a useful animal model for each of these endpoints. This animal model will allow randomized assignment to moderate alcohol or placebo treatment groups, thus avoiding the problems of self-selected populations and self-reported alcohol consumption inherent in human studies. The proposed experiment also offers complete control over alcohol dose, diet, and other variables known to affect disease endpoints. In the proposed experiment, hypothesized mechanisms of alcohol action will be addressed during the early and middle stages of disease development which is not possible using human subjects. Consequently, the use of this animal model obviates the need to wait for relatively rare clinical events to occur in order to obtain reliable measures of disease risk. Our long-term goal is to determine the relative risks/benefits of moderate alcohol consumption by simultaneous assessment of CHD, osteoporosis, and breast cancer risk.

申请人的摘要：虽然过量酒精的有害影响 消费量是广泛的，适度饮酒的影响 不太了解。 目前，人们认为中度酒精 消费降低了冠心病（CHD）的风险，增加了骨骼 密度是抗焦虑，并促进社会互动。 因此，那里 目前似乎对中度饮酒有所好处。 更多的 令人担忧的是中度饮酒可能增加的可能性 乳腺癌的风险，也可能导致过量酒精 消耗。 因此，在中度可能会有风险/利益权衡 饮酒。 我们建议评估中等酒精的影响 卵巢切除 雌性Cynomolgus猴子（Macaca fascicularis），一种有用的动物模型 这些端点中的每一个。 该动物模型将允许随机分配 适度酒精或安慰剂治疗组，从而避免问题 固有的自我选择人群和自我报告的酒精消费 在人类研究中。 拟议的实验还提供了完全控制的 酒精剂量，饮食和其他已知影响疾病终点的变量。 在拟议的实验中，假设的酒精作用机制将 在疾病发展的早期和中期都可以解决 使用人类受试者是不可能的。 因此，使用这种动物 模型消除了需要等待相对罕见的临床事件的需求 为了获得可靠的疾病风险措施。 我们的长期目标是 确定中等饮酒的相对风险/益处 同时评估CHD，骨质疏松症和乳腺癌风险。