POOLED ANALYSIS OF NHANES I/II--RACE, GENDER, AND CHD

NHANES I/II 的汇总分析——种族、性别和 CHD

• 批准号: 2750617
• 负责人: YOULIAN LIAO
• 金额: $ 7.41万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2750617
• 关键词: atherosclerosis; cardiovascular disorder epidemiology; comorbidity; coronary disorder; disease /disorder proneness /risk; gender difference; human data; meta analysis; method development; outcomes research; racial /ethnic difference; statistics /biometry

DESCRIPTION (Adapted from the applicant's abstract) Over the last 25 years, a sustained and marked decline in death rates from coronary heart disease (CHD) has occurred for all major segments of the U.S. population. Recently, however, the decline has proceeded less rapidly in blacks than in whites, and in women than men. These trends have focused further attention on possible heterogeneity in the risk factor patterns among the demographic sub-groups. Previous studies of CHD risk factors in blacks and whites using the First National Health and Examination Survey Epidemiologic Follow-up Study (NHEFS-l, 11-year follow-up), including this group's own work, demonstrate its potential strengths, while at the same time foundering on the problem of low statistical power. With the extension of the follow-up of NHANES-l cohort (1971-1974) to 1987 (14 years) and the completion of 14-year follow-up for NHANES ll cohort (1976-1980), a strong rationale exists to undertake a "pooling project." The resulting data set would provide optimal characterization of CHD risk at the national level. This application proposes to accomplish three principal aims. First, they will determine whether or not the two samples can be effectively pooled. To accomplish this aim, they will assess the distribution of baseline measures and determine whether the same logistic prediction equations fit both studies. Second, they will examine gender-race differences in individual exposure-outcome relationships, patterns of co-morbidity, and population attributable risks. Finally, the fully documented data file will be made available for public use via the Internet.

描述 （根据申请人的摘要改编）在过去25年中，一个持续的 冠心病（CHD）的死亡率明显下降已有 美国人口的所有主要部门发生。 但是，最近， 黑人的下降速度的速度比白人和白人的速度要少。 女人比男人。 这些趋势将进一步的关注集中在可能 人口亚组中风险因素模式的异质性。 先前对黑人和白人冠心病风险因素的研究使用了第一个 国家健康与考试调查流行病学后续研究 （NHEFS-L，11年的随访），包括该小组的作品，证明了 它的潜在优势，同时基于 低统计能力。 随着NHANES-L的随访扩展 队列（1971-1974）至1987年（14年）和14年的完成 NHANES LL队列（1976-1980）的后续措施，存在很强的理由 进行一个“合并项目”。 最终的数据集将提供最佳 国家一级的冠心病风险表征。 该申请建议实现三个主要目标。 首先，他们 将确定是否可以有效汇总这两个样本。 到 实现这一目标，他们将评估基线措施的分布 并确定相同的逻辑预测方程是否适合两者 研究。 其次，他们将检查个体的性别差异 暴露关系关系，合并症的模式和人口 归因风险。 最后，将制作完整的数据文件 可通过互联网公开使用。