ORNITHINE DECARBOXYLASE ANTIZYME (ODC-AZ) IN ORAL CANCER

鸟氨酸脱羧酶抗酶 (ODC-AZ) 在口腔癌中的应用

• 批准号: 2501276
• 负责人: TAKANORI TSUJI
• 金额: $ 4.41万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2501276
• 关键词: Retroviridae; athymic mouse; complementary DNA; enzyme activity; gene expression; gene induction /repression; gene mutation; gene rearrangement; genetic library; genetic promoter element; keratinocyte; messenger RNA; neoplasm /cancer genetics; neoplastic cell; nucleic acid sequence; oral pharyngeal neoplasm; ornithine decarboxylase; polymerase chain reaction; tissue /cell culture; transfection /expression vector; tumor suppressor genes

DESCRIPTION: This is a proposal to test the hypothesis that the ornithine decarboxylase-antizyme gene (ODC-Az) is a tumor suppressor gene in oral cancer Under Aim 1 the tumor suppressing-potential will be evaluated in malignant hamster oral keratinocytes by introducing the gene in an inducible retrovirus system. Under Aim 2 the regulatory region of the gene will be examined in orde to find if loss of expression is due to changes in that region.

描述：这是一个测试鸟氨酸假设的提案 脱羧酶抗酶基因（ODC-Az）是口腔中的抑癌基因 癌症 在目标 1 下，将评估肿瘤抑制潜力 通过将该基因引入诱导型恶性仓鼠口腔角质形成细胞 逆转录病毒系统。 根据目标 2，该基因的调控区域将是 检查以查明表达丧失是否是由于该变化引起的 地区。