NEURAL AND HUMORAL MECHANISMS DURING HYPOVOLEMIA

低血容量期间的神经和体液机制

基本信息

批准号：
2735143
负责人：
TERRY N THRASHER
金额：
$ 20.88万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-07-01 至 2001-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2735143
关键词：
adrenocorticotropic hormone aorta arginine vasopressin atrium baroreceptors blood chemistry cardiovascular function carotid sinus denervation dogs heart innervation hemorrhage hormone regulation /control mechanism hypovolemia neuroendocrine system renin

项目摘要

DESCRIPTION: This proposal is designed to investigatethe mechanism of the release of AVP and ACTH and plasma renin activity in response to hemorrhage. The proposal addresses the relative contribution of atrial cardiac receptors and arterial baroreceptor in these responses as well as their interactions. The investigator found that blocking cardiac receptors with local anesthetics injected into the pericardial space of conscious dogs had no effect on vasopressin release whereas vasopressin release during hemorrhage was more tightly correlated to the decrease in arterial blood pressure. Based on these results he suggested that the atrial receptors are not involved in the release of AVP in hemorrhage or, at least, they are not the dominant influence; thereby challenging traditional concepts concerning the release of AVP. The investigator has devised techniques to expand these studies. These techniques make use of unanesthetized dog preparations in which the aortic baroreceptors as well as one carotid sinus are denervated, while the other carotid sinus can be isolated from the circulation by means of occluding devises and its pressure can be maintained constant. In addition, by means of occluding devises on the thoracic inferior vena cava, venous return can be regulated thereby controlling atrial pressure. Finally, the cardiac receptors can be eliminated by the injection of local anesthetics into the pericardial space. Using this preparation the relative contribution from the cardiac and arterial baroreceptors in the control of AVP, plasma renin and ACTH can be addressed. In addition, the interactions between these receptors can be evaluated. The specific aims of the proposal are: 1) to show that unloading cardiac receptors alone stimulates an increase in plasma renin activity but not an increase in AVP and ACTH in response to thoracic inferior vena cava occlusion; 2) To show that unloading arterial baroreceptor alone can stimulate increases in plasma AVP and ACTH similar to those obtained during systemic hypotension but that the plasma renin activity response is greater when both arterial and atrial receptors are unloaded; and, 3) to show that afferent signals from the heart chronically inhibit renin but not AVP and ACTH secretion in conscious normovolemic dogs.

描述：该建议旨在研究机制响应出血后，AVP和ACTH和血浆肾素活性的释放。该提案解决心房受体的相对贡献这些反应以及它们的相互作用中的动脉压力受体。研究人员发现用局部阻断心脏受体注入有意识狗的心包空间的麻醉药没有对血管加压素释放的影响与动脉血压的降低更加紧密相关。基于这些结果，他建议心房受体不是参与出血中AVP的释放，或者至少不是主导影响；从而挑战有关传统概念释放AVP。研究人员已经设计了扩展这些技术研究。这些技术在主动脉压力受体以及一个颈动脉窦被取消，虽然可以通过手段从循环中隔离另一个颈动脉鼻窦闭塞及其压力可以保持恒定。在另外，通过遮挡胸部下腔静脉的设计，可以调节静脉回流，从而控制心房压力。最后，可以通过注射局部来消除心脏受体麻醉剂进入心包空间。使用此准备亲戚心脏和动脉压力受体的贡献可以解决AVP，血浆肾素和ACTH。另外，互动可以评估这些受体之间。提案的具体目的是：1）证明单独卸载心脏受体会刺激血浆肾素活性的增加，但不增加AVP和ACTH的增加对胸部下腔静脉闭塞的反应； 2）表明卸载单独的动脉压力受体可以刺激血浆AVP和ACTH的增加与全身性低血压中获得的相似，但血浆当动脉和心房受体均肾素活性反应更大卸载； 3）表明发自内心的传入信号长期抑制肾素，但不抑制AVP和ACTH的分泌常规犬。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Interactions between vasopressin and atrial natriuretic peptides.

加压素和心房钠尿肽之间的相互作用。

DOI：
10.1111/j.1749-6632.1993.tb55565.x
发表时间：
1993
期刊：
Annals of the New York Academy of Sciences
影响因子：
5.2
作者：
Thrasher,TN;Ramsay,DJ
通讯作者：
Ramsay,DJ

Cardiac nerve blockade by infusion of procaine into the pericardial space of conscious dogs.

通过将普鲁卡因注入有意识的狗的心包腔来阻断心脏神经。

DOI：
10.1152/ajpregu.1991.260.6.r1176
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
0
作者：
O'Donnell,CP;Scheuer,DA;Keil,LC;Thrasher,TN
通讯作者：
Thrasher,TN

Systolic pressure predicts plasma vasopressin responses to hemorrhage and vena caval constriction in dogs.

收缩压可预测血浆加压素对狗出血和腔静脉收缩的反应。

DOI：
10.1152/ajpregu.2000.279.3.r1035
发表时间：
2000
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
0
作者：
Thrasher,TN;Keil,LC
通讯作者：
Keil,LC

Arterial baroreceptors control plasma vasopressin responses to graded hypotension in conscious dogs.

动脉压力感受器控制清醒狗的血浆加压素对分级低血压的反应。

DOI：
10.1152/ajpregu.2000.278.2.r469
发表时间：
2000
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
0
作者：
Thrasher,TN;Chen,HG;Keil,LC
通讯作者：
Keil,LC

Left heart and arterial baroreceptors interact in control of plasma vasopressin, renin, and cortisol in awake dogs.

清醒狗的左心和动脉压力感受器相互作用，控制血浆加压素、肾素和皮质醇。