METALLOPORPHYRINS SPIN COUPLING AND C60

金属卟啉自旋耦合和 C60

• 批准号: 6012431
• 负责人: CHRISTOPHER A REED
• 金额: $ 26.02万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-06-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6012431
• 关键词: Mossbauer spectrometry; X ray crystallography; biomagnetism measurement; chemical models; chemical structure function; chemical synthesis; chromophore; copper; cytochrome oxidase; divalent metal; electron spin resonance spectroscopy; electronic spectra; ferrocene; free radicals; iron; ligands; metalloporphyrins; molecular energy level; molecular orbital; nuclear magnetic resonance spectroscopy; oxidation reduction reaction; phosphines; stereochemistry; structural biology; superconductivity

This project explores the chemistry of metalloporphyrins, spin coupling phenomena, and C60, all with the goal of discovering fundamental new chemistry that underpins the molecular level understanding of biology and medicine. The bioinorganic chemistry of superstructured metalloporphyrins and fullerenes will be investigated to uncover new multi-metal and multi- electron chemistry. Iron porphyrins with chelated copper or electron reservoir substituents (e.g. C60, ferrocene) will serve as models for cytochrome oxidase. A more diverse selection of metals and ligands (e.g. 'phosphine pincer porphyrin') will allow exploitation of chemistry unique to binucleating ligands. Spin coupling phenomena will be explored, particularly to test concepts of orthogonality of magnetic orbitals. Models for peroxidase Compound I will test the difference between a-1-u and a-2-u porphyrin radical spin coupling to iron and its relationship to porphyrin ruffling. The novel concept of a Magnetochemical Series will be explored with admixed spin iron(III) porphyrins. The fundamental chemistry of C60 will be explored to establish a chemical basis for potential biomedical applications. Emphasis in all of these studies will be placed on the definitive characterization of analytically pure materials by X-ray crystallography and spectroscopic methods, on the discovery of new chemistry, and on the demonstration of relationships to the molecular level chemistry of metalloproteins, particularly hemoproteins. An understanding of this fundamental bioinorganic chemistry must underlie medical approaches to the therapy of metalloprotein disorders (thalassemias, sickle cell anemia, etc.). New ligands and their metal complexes are finding applications as anti-arthritic drugs. C60 has potential applications in photodynamic therapy and as an anti-viral agent.

该项目探讨了金属核蛋白的化学反应，旋转耦合 现象和C60，所有目标都是发现基本新的 基于生物学的分子水平理解和 药品。 超结构金属卟啉的生物无机化学和 将研究富勒烯，以发现新的多金属和多型 电子化学。用螯合铜或电子的铁卟啉 储层取代基（例如C60，二革新）将作为模型 细胞色素氧化酶。多种多样的金属和配体选择（例如 “磷pincer卟啉”）将允许化学独特的剥削 进行双核配体。 将探索自旋耦合现象， 特别是测试磁轨道正交性的概念。 过氧化物酶化合物的模型我将测试A-1-U之间的差异 和a-2-u卟啉自由基自旋耦合与铁及其与之的关系 卟啉荷兰。磁化学系列的新颖概念将是 用混合旋转铁（III）卟啉探索。 基本 将探索C60的化学性能以建立化学基础 潜在的生物医学应用。所有这些研究的重点将 放置在分析纯的明确表征上 X射线晶体学和光谱方法的材料，在 发现新的化学反应，以及与 金属蛋白的分子水平化学，特别是 血蛋白。 对这种基本生物无机化学的理解必须是 疗法的金属蛋白疾病治疗 （Thalassexias，镰状细胞贫血等）。新配体及其金属 复合物发现应用是抗关节药。 C60有 潜在的光动力疗法和抗病毒药物的应用。