PSYCHOBIOLOGY OF RHYTHMS IN DIURNAL MAMMALS--II

昼间哺乳动物节律的心理生物学--II

• 批准号: 2472652
• 负责人: LAURA SMALE
• 金额: $ 18.27万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2472652
• 关键词: Rodentias; brain metabolism; circadian rhythms; deoxyglucose; embryo /fetus tissue transplantation; fos protein; gene expression; glucose transport; gonadotropin releasing factor; hormone regulation /control mechanism; immediate early protein; immunocytochemistry; light adaptations; nervous system transplantation; neural information processing; ovariectomy; psychobiology; regulatory gene; stereotaxic techniques; suprachiasmatic nucleus

DESCRIPTION (adapted from applicant's abstract): The proposed research is aimed at determining how the neural mechanisms controlling daily rhythms differ in nocturnal and diurnal mammals. A small group of neurons in the mammalian brain called the suprachiasmatic nucleus (SCN) is responsible for the generation of 24 hour rhythms. To date, most research into the SCN and how it controls circadian rhythms has been done with nocturnal rodents. Until recently there has been no suitable diurnal rodent model with which to investigate these issues. These investigators have been working with a diurnal rodent, Arvicanthis niloticus, that they recently imported to the United States from East Africa. In the research proposed here they intend to use these rodents to determine how the neural structures controlling circadian rhythms differ in nocturnal and diurnal animals. The first objective is to compare nocturnal and diurnal animals with respect to rhythms in the concentration of a molecule that regulates gene expression, within the SCN and several brain regions to which it projects. Second, the investigators will compare rhythms in metabolic activity of the SCN in nocturnal and diurnal animals. Third, they will use SCN transplants to determine whether activity rhythms of diurnal and nocturnal animals differ because of differences within the SCN or differences in responsiveness to signals emanating from the SCN. Finally, they will evaluate rhythms within one brain region that receives signals from the SCN and controls rhythms in hormone secretion. It is important to understand these issues because the circadian system influences virtually every physiological and behavioral variable, and this influence is profoundly different in nocturnal and diurnal species.

描述（根据申请人的摘要改编）：拟议的研究是 旨在确定如何控制每日节奏的神经机制 夜间和昼夜哺乳动物不同。 一小群神经元 哺乳动物脑称为肌核（SCN）负责 24小时节奏的一代。 迄今为止，大多数研究SCN和 它如何控制昼夜节律是通过夜间啮齿动物完成的。 直到最近，还没有合适的昼夜啮齿动物模型 调查这些问题。 这些调查人员一直在与 昼夜啮齿动物，arvicanththis niloticus，他们最近进口到 来自东非的美国。 在这里提出的研究中，他们打算 使用这些啮齿动物来确定如何控制神经结构 夜间和昼夜动物的昼夜节律不同。 第一个 目的是比较夜间和昼夜动物 调节基因表达的分子浓度的节奏， 在SCN和IT投影的几个大脑区域内。 第二， 研究人员将比较SCN代谢活性的节奏 夜间和昼夜动物。 第三，他们将使用SCN移植 确定昼夜和夜间动物的活性节奏是否有所不同 因为SCN内的差异或响应能力的差异 SCN发出的信号。 最后，他们将评估内在的节奏 一个从SCN接收信号并控制节奏的大脑区域 激素分泌。 了解这些问题很重要，因为昼夜节律系统 影响几乎每个生理和行为变量，这 夜间和昼夜物种的影响截然不同。