EPIDEMIOLOGY OF MARINE FATTY ACIDS AND PREECLAMPSIA

海洋脂肪酸与先兆子痫的流行病学

• 批准号: 2673818
• 负责人: MICHELLE A. WILLIAMS
• 金额: $ 21.11万
• 依托单位: SWEDISH MEDICAL CENTER, FIRST HILL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2673818
• 关键词: alcoholic beverage consumption; antioxidants; biomarker; blood chemistry; body physical activity; clinical research; dietary constituent; disease /disorder proneness /risk; eicosanoids; epidemiology; fatty acid biosynthesis; human pregnant subject; interview; marine animal oil; nutrition related tag; peroxidation; preeclampsia; pregnancy toxemia /hypertension; unsaturated fatty acids; urinalysis; women's health

DESCRIPTION: (Adapted from Investigator's Abstract) Preeclampsia, the third leading cause of maternal mortality in the United States, is an important cause of preterm delivery, fetal growth retardation, and perinatal mortality. Uteroplacental hypoperfusion is thought to be the primary defect in preeclampsia. Endothelial cell damage is also important in the pathogenesis of preeclampsia. Previous investigators have focused on the cause of these vascular insults. Findings from several disciplines indicate that preeclampsia is associated with excessive lipid peroxidation, oxidant-antioxidant imbalance, as well as an imbalance in n-3 and n-6 polyunsaturated fatty acids, and in thrombooxane and prostacyclin synthesis. Presently it is unknown whether these features precede preeclampsia or are secondary to the disease process. The authors propose to conduct a prospective cohort study of pregnant nulliparous women. The overall aim of the proposed research is to evaluate whether, and to what extent, maternal intake of dietary marine fatty acids and antioxidant vitamins are associated with risk of preeclampsia. The authors will collect maternal blood and urine specimens from a cohort of 1500 women during the first trimester of pregnancy. At the same time, information regarding medical and behavioral characteristics will be collected by interview. Medical records will be reviewed in order to collect information regarding pregnancy outcome. Blood and urine specimens will be processed and stored at -70C until analysis. Maternal intake of marine fatty acids and antioxidant vitamins will be assessed using biochemical and dietary methods. Eicosanoids and indicators of lipid peroxidation will also be evaluated. Using a nested case-cohort sampling design, the authors will identify 90 women with preeclampsia and an equal number of women with gestational hypertension. One hundred and fifty women randomly selected from the entire study cohort (N- 1500) will serve as a single reference group for all individuals sampled. Statistical analyses will focus on determining: (1) the extent to which lipid peroxidation and eicosanoid synthesis in the first trimester are associated with subsequent risk of preeclampsia and gestational hypertension, respectively; and (2) whether these metabolic factors are associated with maternal diet. The investigators state that clinical applications of study findings may result in early identification of women at risk of preeclampsia and an effective intervention.

描述：（改编自研究者摘要）先兆子痫， 美国孕产妇死亡的第三大原因是 是导致早产、胎儿生长迟缓的重要原因 围产期死亡率。 子宫胎盘灌注不足被认为是 先兆子痫的主要缺陷。 内皮细胞损伤也 在先兆子痫的发病机制中具有重要意义。 以前的调查员 重点关注这些血管损伤的原因。 调查结果来自 多个学科表明先兆子痫与 过度的脂质过氧化、氧化-抗氧化失衡以及 n-3 和 n-6 多不饱和脂肪酸不平衡，以及 血栓素和前列环素的合成。 目前尚不清楚 这些特征是先兆子痫还是继发于先兆子痫 疾病过程。 作者建议进行一项前瞻性队列研究 对未生育孕妇的研究。 拟议的总体目标 研究的目的是评估母亲是否摄入以及在何种程度上摄入 膳食海洋脂肪酸和抗氧化维生素与 先兆子痫的风险。 作者将收集母亲的血液和尿液 样本取自 1500 名女性在妊娠前三个月的队列 怀孕。 同时，有关医疗和 行为特征将通过访谈收集。 医疗的 将审查记录以收集有关 妊娠结果。 血液和尿液样本将被处理并 分析前储存于-70°C。 母亲摄入海洋脂肪酸和 抗氧化维生素将使用生化和饮食进行评估 方法。 类二十烷酸和脂质过氧化指标也将被 评价。 使用嵌套案例队列抽样设计，作者将 确定了 90 名患有先兆子痫的女性以及同等数量的患有先兆子痫的女性 妊娠高血压。 随机抽取一百五十名女性 来自整个研究队列 (N-1500) 的样本将作为单一参考 所有样本个体的分组。 统计分析将集中于 确定：（1）脂质过氧化和类二十烷酸的程度 妊娠早期的合成与随后的风险相关 分别为先兆子痫和妊娠期高血压； (2) 是否 这些代谢因素与母亲的饮食有关。 这 研究人员表示，研究结果的临床应用可能 从而及早识别出有先兆子痫风险的女性，并 有效干预。