PRENATAL BLOOD AND BONE LEAD EFECTS ON INFANT OCULOMOTOR FUNCTION

产前血液和骨铅对婴儿动眼功能的影响

• 批准号: 6240117
• 负责人: STEPHEN J ROTHENBERG
• 金额: $ 4.33万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6240117
• 关键词: X ray spectrometry; atomic absorption spectrometry; clinical research; embryo /fetus toxicology; gestational age; human pregnant subject; human subject; infant human (0-1 year); lead; prenatal diagnosis; prenatal stress; psychomotor function; questionnaires; saccades; smooth pursuit eye movement; statistics /biometry

The project will investigate the role of prepregnancy maternal bone lead and prenatal maternal blood lead upon alterations in infant saccadic and smooth pursuit eye movements. The project will study a traditionally underserved, primarily Latino and African-American inner city population in South Central Los Angeles at the King/Drew Medical Center. The target population has higher blood lead levels than the national average. The study seeks to determine if maternal blood lead during specific periods of pregnancy, representing different phases of fetal development, are more highly correlated with altered oculomotor function than maternal blood lead at other periods of pregnancy. It will determine if the effects of prenatal lead exposure can be measured from six months to two years of age. It will also see if postnatal blood lead levels predict altered oculomotor function. The study will determine if maternal bone lead contributes to altered oculomotor development with or without influence upon maternal blood lead level during pregnancy. It will determine which of the two lead exposure indices better predict developmental deficit. Mothers will be recruited near the end of one pregnancy and followed until their next pregnancy to obtain a prepregnancy bone lead. Maternal blood lead will be measured in the interpregnancy interval and during pregnancy while maternal bone lead will be measured only during the interpregnancy interval. Infant blood lead will be measured every 6 months from birth. Blood lead will be measured by atomic absorption spectrometry with graphite furnace. Bone lead will be measured by K-band X-ray fluorescence with 109Cd source, fast spectroscopy amplifier and advanced spectral analysis algorithms. Oculomotor function will be measured by infrared pupil-corneal reflection television scanner with automatic head tracking. Saccade parameters of latency and accuracy will be measured, along with smooth pursuit parameters of velocity gain using step-ramp horizontally displaced visual targets. Multiple regression techniques will be used to control for confounding and control variables, such as nutrition, illness and injury, in order to test the effects of the lead measures upon oculomotor function. Oculomotor function is a vital behavior that allows the infant to orient itself to acquire visual information. This function is primary to adequate development of the child. The tests are culture- free and validation of lead effect upon them will permit their wider use in any population. Bone lead measurements may supplement traditional blood lead measurements in determining exposure limits for regulatory purposes.

该项目将调查孕前母骨铅的作用 和产前孕产妇的血液会改变婴儿saccadic和 光滑的追捕眼动。 该项目将研究传统 服务不足的，主要是拉丁裔和非裔美国人内城的人口 在洛杉矶中南部的国王/德鲁医疗中心。 目标 人口的血铅水平高于全国平均水平。 这 研究旨在确定在特定时期的孕产妇铅是否 怀孕代表胎儿发育的不同阶段，更多的是 与母体血液相比，与动眼功能的改变高度相关 在其他怀孕期间领先。 它将确定是否影响 产前铅暴露可以从六个月到两年 年龄。 它还将查看产后血铅水平是否预测发生了变化 眼动函数。 该研究将确定母体骨骼是否铅 有助于有或没有影响的动眼发育的改变 在怀孕期间产妇血铅水平。 它将确定哪个 在两个铅暴露指数中，可以更好地预测发育不足。 母亲将在一次怀孕结束后招募，然后直到 他们的下一次怀孕以获得孕前骨头。 母血 铅将在妊娠间隔和怀孕期间测量 虽然只有在室内期间测量产妇的铅铅 间隔。 从出生后每6个月测量婴儿的血液铅。 血铅将通过原子吸收光谱法测量 石墨炉。 骨头将通过K波段X射线荧光测量 具有109CD源，快速光谱放大器和高级光谱 分析算法。 眼动功能将通过红外线测量 带有自动头部跟踪的学生反射电视扫描仪。 将测量延迟和准确性的扫视参数 使用阶梯式跨度水平的速度增益的平滑追踪参数 流离失所的视觉目标。 多元回归技术将用于 控制和控制变量，例如营养，疾病 和伤害，以测试铅措施对 眼动函数。 眼动函数是一种至关重要的行为，允许 婴儿定向自己获取视觉信息。 此功能 是儿童充分发育的主要发展。 测试是培养的 自由和验证铅效应将允许其更广泛的使用 在任何人群中。 骨头铅测量可能会补充传统 确定调节暴露限制的血铅测量 目的。