FETAL NEUROBEHAVIORAL DEVELOPMENT & POSTNATAL CONTINUITY

胎儿神经行为发育

• 批准号: 2673629
• 负责人: Janet A. Di Pietro
• 金额: $ 20.87万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2673629
• 关键词: behavior prediction; behavioral /social science research tag; behavioral habituation /sensitization; child psychology; clinical research; computer program /software; developmental neurobiology; embryo /fetus; gestational age; human subject; infant human (0-1 year); longitudinal human study; neuropsychology; newborn human (0-6 weeks); prenatal stress; psychophysiology; ultrasonography

DESCRIPTION (Adapted from the Applicant's Abstract): Knowledge about the ontogeny of human development prior to birth, and the contribution of the prenatal period to postnatal life has been hampered by the lack of access to the fetus. The goals of this project are to document normal fetal development during the latter half of gestation; to investigate predictive relations from the fetus to the infant; and to elucidate the role of maternal psychophysiology on fetal and infant development. Seven hypotheses are proposed: (i) FHR reactivity increases over the second half of gestation, (ii) Fetuses can habituate to external stimulation and the rate will increase over gestation; (iii) Increased maternal stress is associated with decreased FHR variability, increased activity and greater reactivity; (iv) Fetal behavior will be affected by maternal physiological and psychological state (induced maternal stress will associate with increased FHR and disorganized patterns of fetal movement and state); (v) Fetuses of multiparous women will have accelerated fetal development; (vi) There will be neurobehavioral continuity between fetuses and infants; and (vii) Maternal stress effects will influence infant behavior. The conceptual orientation is that fetal neurobehavior reflects the maturational status of the nervous system, and that individual differences in neural regulatory capacity are manifested within the normal range at each gestational age. The project employs a longitudinal design at six gestational ages. A total of 120 subjects, stratified for parity, will be tested. At each visit fetal (HR, motor activity, behavior) and maternal (heart period, respiratory rate, etc) measures will be recorded simultaneously during 50 undisturbed minutes. Data will be digitized and processed with customized software. Maternal affective characteristics will be determined at the onset of the study and appraisal of daily stressors will be measured at each visit. Two other studies are embedded in the design. Fetal habituation will be tested at 20, 28 and 36 weeks by measuring FHR and ultrasonographic indices of fetal movement in response to a rattle. Manipulation of maternal state will be done at 24 and 32 weeks by engaging the women in a video game and testing with a phrase association task. Infants will be tested at 4 and 9 months on a variety of measures.

描述（改编自申请人的摘要）：有关 出生前人类发展的个体发育，以及 由于缺乏进入后，产后生命的产前时期受到了阻碍 胎儿。 该项目的目标是记录正常胎儿 妊娠后半段的发展；研究预测 从胎儿到婴儿的关系；并阐明 孕产妇心理生理学关于胎儿和婴儿发育。 七个假设 提出：（i）FHR反应性在后半部分增加 妊娠，（ii）胎儿可以习惯于外部刺激和速率 妊娠将增加； （iii）孕产妇压力增加与 随着FHR的可变性降低，活性增加和反应性更高； （iv）胎儿行为将受到母性生理和 心理状态（诱发母体压力将与增加 FHR和胎儿运动和状态的混乱模式）； （v）胎儿 多方妇女将加速胎儿发育； （vi）那里 是胎儿和婴儿之间的神经行为连续性；和（vii） 孕产妇的压力影响将影响婴儿行为。 概念 取向是胎儿神经行为反映了 神经系统以及神经调节的个体差异 容量在每个胎龄的正常范围内表现出来。 该项目采用六个妊娠年龄的纵向设计。 总共 将测试120名受试者中的120名受试者。 每次访问胎儿 （人力资源，运动活动，行为）和母体（心脏周期，呼吸率， 等）将在50分钟内同时记录措施。 数据将数字化并使用自定义软件进行处理。 母亲 情感特征将在研究开始时确定 每次访问时都会衡量对日常压力源的评估。 另外两个 研究嵌入了设计中。 胎儿习惯将在20时测试 通过测量胎儿的FHR和超声指数28和36周 响应拨浪鼓的运动。 孕产妇国家的操纵将是 通过让女性参与视频游戏和测试，在24和32周完成 通过短语关联任务。 婴儿将在4个月和9个月的时间进行测试 各种措施。