BRAIN AND ATTENTION IN SUBSTANCE ABUSERS WITH PTSD

患有创伤后应激障碍 (PTSD) 的药物滥用者的大脑和注意力

• 批准号: 2397999
• 负责人: WILLIAM E SEMPLE
• 金额: $ 33.3万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2397999
• 关键词: attention deficit disorder; auditory deprivation; behavior disorders; behavioral /social science research tag; brain disorder diagnosis; brain disorders; brain mapping; butanols; cingulate gyrus; clinical research; cocaine; comorbidity; gender difference; human subject; positron emission tomography; posttraumatic stress disorder; statistics /biometry; substance abuse related disorder

DESCRIPTION: (Applicant's Abstract) The broad objectives of this project are to further define attention impairment and associated brain function abnormalities in substance abusers (SA) with co-morbid posttraumatic stress disorder (PTSD). The relative contributions of substance abuse and PTSD would be assessed. Control state PET scans will clarify the interpretation of brain changes seen during attention. Since PTSD symptomatology is present in 25-45% of SA who seek treatment, attention and cognitive impairment in SA-PTSD represents both a vulnerability and treatment relapse factor in a large segment of the substance abusing population. Females constitute nearly 40% of SA, and appear to have increased rates of co-morbid SA-PTSD compared to males. The specific objectives of this project are to examine auditory continuous performance task (ACPT) impairment and related brain dysfunction in cocaine abusers with and without co-morbid PTSD who are at least 4 weeks drug free. Ongoing regional cerebral blood flow (rCBF) studies of attention using '50-butanol and positron emission tomography (PET) will be expanded to include women to test the generality of findings in males. SA-PTSD, SA-Only, PTSD-Only, and normal groups will be compared. Six serial PET scans using 0-15 butanol will assess rCBF in frontal, parietal, and anterior cingulate cortex attention substrates during rest, the ACPT, and an auditory tone/no response control state. Image analysis will incorporate region of interest and statistical parametric mapping techniques. Additional clinical and neuropsychological testing will assess symptomatology, pre-morbid characteristics, and cognitive impairment. Hypotheses to be tested include: 1) SA-PTSD patients will show impaired attention compared to SA-Only, PTSD-Only, and normal controls; 2) SA-PTSD patients will show reduced parietal rCBF compared to normal controls and PTSD-Only, with SA-Only intermediate; 3) Compared to normals, SA-PTSD and SA-Only will have decreased rCBF at anterior cingulate during the ACPT; 4) SA-PTSD and SA-Only patients will have normal rCBF levels and activation of the right prefrontal cortex; 5) Females with SA-PTSD will have attention impairment and parietal abnormalities like those seen in males; 6) Attention performance impairment will be correlated with brain attention substrate dysfunction. The proposed project seeks to identify a brain pathophysiology for behavioral impairment related to vulnerability for substance abuse and treatment relapse.

描述：（申请人的摘要） 该项目的广泛目标是进一步定义注意力 药物滥用和相关的大脑功能异常 （SA）与创伤后应激障碍（PTSD）合并。 亲戚 将评估药物滥用和PTSD的贡献。 控制状态 PET扫描将阐明对大脑变化的解释 注意力。 由于有25-45％的SA寻求PTSD症状学 SA-PTSD中的治疗，注意力和认知障碍代表 大部分的脆弱性和治疗复发因子 滥用种群的物质。 女性占SA的近40％，并且 与男性相比，合并症SA-PTSD的发生率似乎增加了。 这 该项目的具体目标是检查听觉连续 可卡因的性能任务（ACPT）损伤和相关的大脑功能障碍 至少有4周不含药物的虐待者有或没有合并症PTSD。 正在进行的区域脑血流（RCBF）研究使用 '50-丁醇和正电子发射断层扫描（PET）将扩展到 包括女性来测试男性发现的普遍性。 SA-PTSD， 将比较仅SA，仅PTSD和正常组。 六个连环宠物 使用0-15丁醇扫描将评估额叶，顶和前部的RCBF 休息期间，ACPT和听觉的扣带皮层注意底物 音调/无响应控制状态。 图像分析将合并 兴趣和统计参数映射技术。 附加临床 神经心理学测试将评估症状学 特征和认知障碍。 要测试的假设包括： 1）SA-PTSD患者与仅SA的患者相比会显示出受损的关注 仅PTSD和正常对照； 2）SA-PTSD患者将显示降低 与正常对照组和仅PTSD相比，顶叶RCBF（仅SA） 中间的; 3）与正常人相比，SA-PTSD和SA-PLY将具有 在ACPT期间，在前扣带回时RCBF降低； 4）SA-PTSD和仅SA 患者将具有正常的RCBF水平和右前额叶的激活 皮质； 5）患有SA-PTSD的女性将患有注意力障碍和顶叶 像男性中看到的异常一样； 6）注意性能障碍 将与大脑注意力底物功能障碍相关。 提议 项目旨在确定行为障碍的脑病理生理学 与药物滥用和治疗复发的脆弱性有关。