COMPLIANCE CHAMBERS FOR ARTIFICIAL HEART IMPLANTS

人工心脏植入物的顺应室

• 批准号: 2716914
• 负责人: JUMARASWAMY JAYARAJ
• 金额: $ 9.81万
• 依托单位: FOSTER-MILLER, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 1999-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2716914
• 关键词: auxiliary heart prosthesis; bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biomaterial interface interaction; biomaterials; biomedical equipment development; circulatory assist; clinical biomedical equipment; diffusion; heart prosthesis; laboratory mouse; laboratory rabbit; liquid crystal; polymers; tensile strength

DESCRIPTION (Adapted from applicant's abstract): The intrathoracic compliance chamber (ICC) is the most successful solution to the variable volume problem of a totally implanted pulsatile artificial heart. However, existing designs are compromised by the rate at which gas permeates through he chamber walls, given that all polymeric membranes are subject to some degree of gas permeation. Given this limitation, percutaneous gas refills would be required at frequent intervals, measured in weeks. It is the applicants' hypothesis that this limitation can be remedied by the use of liquid crystal polymers (LCPs), a material class of remarkable mechanical properties, high chemical inertness, and extremely low permeability (essentially equivalent to glass). The applicants proposes to develop the materials and processes for the fabrication of vastly improved ICCs. The applicants plan to demonstrate that LCPs have the biocompatibility, low permeability, high fatigue resistance, and sufficient manufacturability to be ideal candidates for ventricular assist system and artificial heart compliance chambers. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：胸腔内 合规室 (ICC) 是针对变量的最成功的解决方案 完全植入的搏动人工心脏的体积问题。 然而，现有的设计受到气体速率的影响 考虑到所有聚合物膜都是通过室壁渗透的 受到一定程度的气体渗透。 鉴于此限制， 需要频繁地进行经皮气体补充，测量 几周后。 申请人假设该限制可以是 通过使用液晶聚合物（LCP）来弥补，液晶聚合物是一种材料 卓越的机械性能、高化学惰性和极其 低渗透性（基本上相当于玻璃）。 申请人 提议开发用于制造的材料和工艺 极大地改进了 ICC。 申请人计划证明 LCP 具有生物相容性， 低渗透性、高抗疲劳性、充足的 可制造性成为心室辅助系统的理想候选者 人造心脏顺应室。 拟议的商业应用：不可用