NEURAL SUBSTRATES OF AVERSION DURING OPIOID WITHDRAWAL

阿片类药物戒断期间厌恶的神经基础

• 批准号: 2770072
• 负责人: GREGORY Olaf HJELMSTAD
• 金额: $ 2.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2770072
• 关键词: avoidance behavior; behavioral /social science research tag; dopamine antagonists; drug abuse chemotherapy; drug addiction; drug withdrawal; ethology; gamma aminobutyrate; glutamates; laboratory rat; morphine; naloxone; neural transmission; neuropharmacology; nonhuman therapy evaluation; nucleus accumbens; opioid receptor; psychopharmacology

DESCRIPTION: (Applicant's Abstract) The overall goal of this research proposal is to investigate the neural mechanisms underlying the aversiveness of opioid withdrawal. In this project, behavioral experiments will be conducted to study the aversiveness of opioid antagonists micro injected into the nucleus accumbens of morphine dependent rats. Specifically, mu a and kappa selective opioid antagonists will be tested for conditioned place aversion, and the potential interaction between dopamine and this aversion will be tested. Concomitantly, in vitro brain slice techniques will be used to study the effects of opioid on the cellular properties of neurons from the shell of the nucleus accumbens. Furthermore, potential changes in these properties will be studied by preparing slices from morphine dependent rats. The results of these experiments should lead to an increased understanding of the specific neural circuitry involved in opioid withdrawal, which may be helpful in developing treatments for overcoming opioid addiction in humans.

描述：（申请人的摘要） 该研究建议的总体目标是调查神经 阿片类药物提取的厌恶性的基础机制。 在这个 项目，将进行行为实验以研究厌恶性 阿片类拮抗剂的微观注射到吗啡的伏隔核中 依赖的大鼠。 具体而言，MU A和Kappa选择性阿片类拮抗剂 将测试有条件的位置厌恶和潜在的相互作用 在多巴胺和这种厌恶之间将进行测试。 同时在体外 脑切片技术将用于研究阿片类药物对 来自伏隔核的神经元的细胞特性。 此外，这些特性的潜在变化将由 从吗啡依赖性大鼠制备切片。 这些结果 实验应导致对特定神经的了解 涉及阿片类药物提取的电路，这可能有助于开发 克服人类阿片类药物成瘾的治疗方法。