MAP THE SUSCEPTIBILITY GENE IN CHINESE SLE SIBPAIRS

绘制中国 SLE SIBP 对的易感基因图谱

• 批准号: 2695510
• 负责人: BETTY P TSAO
• 金额: $ 2.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2695510
• 关键词: Chinese; alleles; clinical research; family genetics; genetic markers; genetic polymorphism; genotype; human subject; linkage mapping; siblings; systemic lupus erythematosus

The parent project for this FIRCA application is an R01 grant to determine whether five candidate human chromosomal regions confer major susceptibility to SLE. The candidate regions were identified by mouse homologues, and will be studied by linkage and association methods in 300 multiplex families ascertained through UCLA clinics, which was intended to be an ethnically heterogeneous mix, since one of the hypotheses is that SLE-predisposing genes will be conserved across ethnic groups. This group has reported evidence for linkage of SLE to markers on chromosome 1q41-q42, and nonparametric allele sharing methods among affected sib pairs seemed to suggest that the greatest proportion of allele sharing occurred in the Asian subset, which included 10 sib pairs of southern Han Chinese descent. Wishing to extend upon this finding in an ethnically homogeneous subset, Dr. Tsao proposes a collaboration with investigators in the Department of Rheumatology at Ren Ji Hospital in Shanghai, China. The goals of the FIRCA grant are to identify and enroll 100 Chinese SLE-affected sibpair families, to genotype blood samples or buccal swabs with markers densely located in the candidate region, and to analyze the data using nonparametric linkage and association methods.

此FIRCA申请的父项目是R01的赠款 确定五个候选人类染色体区域是否授予专业 对SLE的敏感性。 候选区域通过鼠标识别 同源物，并将通过链接和关联方法研究 300个多路复用家庭通过UCLA诊所确定 打算是一种种族异质的混合物，因为其中一个 假设是在跨越SLE的基因将在跨越 族裔。 该小组报告了SLE连接到的证据 染色体1q41-Q42的标记和非参数等位基因共享方法 在受影响的SIB对中，似乎表明了最大的比例 等位基因共享发生在亚洲子集中，其中包括10个SIB 成对的南部中国血统。 希望在种族均匀的子集中扩展这一发现， TSAO博士建议与部门的调查人员合作 中国上海的Ren Ji医院风湿病学。 目标的目标 FIRCA Grant将识别和注册100个受中国SLE影响的Sibpair 家庭，用于基因型血液样本或颊拭子，并密集 位于候选区域，并使用 非参数链接和关联方法。