INTERACTIONS AND ACTIVATION OF THE FSH RECEPTOR

FSH 受体的相互作用和激活

• 批准号: 2518552
• 负责人: Tae H. Ji
• 金额: $ 20.43万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2518552
• 关键词: follicle stimulating hormone; hormone receptor; intermolecular interaction; protein structure function; receptor binding; receptor expression; tissue /cell culture

DESCRIPTION (Adapted from the Investigator's Abstract): The goal of this proposal is to study the activation mechanism of the FSH receptor (FSH-R). In Aim 1, the C-terminal residues of the FSH-a subunit will be examined to determine conclusively which amino acid(s) is involved in receptor activation, which might be involved in receptor binding, and what the structural and functional relationships of these amino acids are. In Aim 2, the C-terminal half of the FSH-R will be investigated to identify the amino acid residues that are responsible for receptor activation and to determine their roles in receptor activation. In Aim 3, the high affinity hormone contact points in the N-terminal half will be identified and the role of amino acids in hormone binding determined.

描述（改编自研究者的摘要）：本研究的目标 提案是研究FSH受体（FSH-R）的激活机制。 在目标 1 中，将检查 FSH-a 亚基的 C 端残基以 最终确定受体涉及哪些氨基酸 激活，可能与受体结合有关，以及 这些氨基酸的结构和功能关系是。 在目标 2 中， 将研究 FSH-R 的 C 端一半以鉴定氨基 负责受体激活并确定的酸残基 它们在受体激活中的作用。 在目标 3 中，高亲和力激素 N 端半部的接触点将被识别，并且其作用 确定激素结合中的氨基酸。