DYNAMICS OF THE GROWTH AND DEVELOPMENT OF BONE

骨骼生长和发育的动力学

• 批准号: 2575689
• 负责人: A L YERGEY
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2575689
• 关键词: adolescence (12-20); bone development; bone metabolism; calcium metabolism; child (0-11); clinical research; hormone therapy; human subject; human therapy evaluation; osteogenesis imperfecta; somatotropin

The effect of recombinant human growth hormone, hGH, treatment on Ca metabolism and growth is being investigated in patients with Osteogenesis Imperfecta Type III in collaboration with J. Marini, HDB. Fractional absorption of dietary calcium and the rate of Ca distribution within the body is studied in these patients before and after treatment with hGH. Preliminary results of from 5 subjects show an apparent decrease in fractional absorption of dietary calcium (0.29 +/- 0.19 pre treatment vs 0.14 +/- 0.11 post treatment). At the same time an increase in both the whole body exchangeable pool (TEP = 265 +/- 95mg/kg pre treatment vs 673 +/- 616mg/kg post treatment) and rate of calcium accretion to bone (Vo+ = 94 +/- 29mg/kg/d pre treatment vs 142 +/- 75mg/kg/d post treatment) was observed. While suggestive, the variance in the mean values of these results is too great to be significant at the present time. Further studies to confirm these observations are underway.

重组人类生长激素，HGH，治疗对CA的影响 成骨患者正在研究代谢和生长 Inperfecta III型与HDB J. Marini合作。 分数 饮食钙的吸收和CA分布速率 在用HGH治疗前后，对这些患者进行了研究。 来自5名受试者的初步结果显示明显减少 饮食钙的分数吸收（0.29 +/- 0.19 PRE治疗与 0.14 +/- 0.11治疗后）。 同时增加了 全身可交换池（TEP = 265 +/- 95mg/kg Pre Pre Pre Breates vs 673 +/- 616mg/kg治疗后）和钙的钙含量（vo+） = 94 +/- 29mg/kg/d PRE治疗与142 +/- 75mg/kg/d治疗后是 观察到。 虽然暗示性，但这些平均值的差异 目前的结果太大了，目前很重要。更远 确认这些观察结果的研究正在进行中。