EPIDEMIOLOGY OF VENOUS DISEASE

静脉疾病的流行病学

• 批准号: 2460095
• 负责人: MICHAEL H CRIQUI
• 金额: $ 54.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2460095
• 关键词: age difference; aging; angiocardioultrasonography; blood vessel occlusion; body physical activity; body physical characteristic; cardiovascular disorder epidemiology; clinical research; diet; female; gender difference; hormone therapy; human middle age (35-64); human old age (65+); human subject; noninvasive diagnosis; nutrition related tag; oral contraceptives; parity; peripheral blood vessel disorder; plethysmography; quality of life; racial /ethnic difference; sign /symptom; smoking; telangiectasia; varicose veins; vein occlusion; venous thrombosis

Venous disease is commonplace, more prevalent in women, increases with age, and is a major cause of morbidity. Between 6 and 30% of all medical expenditures for cardiovascular disease are for venous disease. Despite these facts, the basic epidemiology of venous disease has received limited attention. Even the definition of peripheral venous disease varies widely, often confusing symptoms and signs with demonstrable pathophysiologic abnormalities. The proposed project has four specific aims. The first specific aim is to determine the overall, and age, sex, and ethnic-specific, prevalence of peripheral venous disease in a stratified multiethnic random sample of 400 men and women aged 40-79 years. Three specific categories of venous disease will be defined: 1) telangiectasias and flat reticular veins; 2) superficial venous disease without deep valvular incompetence or obstruction; 3) deep venous disease, with valvular incompetence or obstruction. Varicose veins are typically but not invariably present in the latter two categories. These three categories will be diagnosed by an ordered non-invasive evaluation, including visual inspection, with photographic documentation of abnormal findings, and duplex color sonography to diagnose valvular incompetence and venous obstruction. The second specific aim is to evaluate the sensitivity, specificity, and predictive value of each f the traditional signs and symptoms of venous disease for each of the three categories of venous disease signs and symptoms to be evaluated include aching, itching, swelling and edema, heaviness, cramps, nocturnal restless legs, pigmentation, induration, ulcers, and the Trendelenburg test. The third specific aim is to evaluate risk factors for each of the above three categories-of venous disease. Risk factors to be assessed include age; sex; ethnicity; socio- economic status; height; weight; obesity; exercise; blood pressure; standing vs. sitting in daily activities; family history of venous disease; cigarette smoking; alcohol consumption; diet; constipation; constrictive clothing; aspirin use; use of selected other medications; history of hernia, flat feet, or other conditions associated with connective tissue laxity; parity; se of estrogens or progestins; age at menarche; age at menopause; and concomitant arterial disease. The fourth specific aims is to evaluate the degree of morbidity and interference with daily activities resulting from venous disease, using the Quality of Well Being (QWB) scale developed at UC San Diego. This study should provide accurate estimates of the extent of peripheral venous disease, contribute to more efficient diagnosis, allow insight on how to prevent or ameliorate this condition through risk factor modification, and will provide quantitative estimates of the daily burden this disease imposes on patients.

静脉疾病很常见，女性更常见，随着年龄的增长而增加 年龄，是发病的主要原因。 占所有医疗费用的 6% 至 30% 用于心血管疾病的支出用于静脉疾病。 尽管 这些事实表明，静脉疾病的基本流行病学已得到证实 有限的关注。 甚至外周静脉疾病的定义 差异很大，经常将症状和体征与明显的症状和体征混淆 病理生理异常。 拟议项目有四个具体目标。 第一个具体目标是 确定总体患病率以及年龄、性别和种族特定患病率 分层多种族随机样本中外周静脉疾病的调查 400 名年龄在 40-79 岁之间的男性和女性。 三个具体类别 静脉疾病的定义是：1）毛细血管扩张和平网状 静脉； 2）无深部瓣膜关闭不全的浅静脉疾病 或阻碍； 3）深静脉疾病，瓣膜功能不全或 梗阻。 静脉曲张通常但并非总是存在于 后两类。 这三类可通过以下方式诊断： 有序的非侵入性评估，包括目视检查， 异常发现的照片记录和双面彩色 超声检查诊断瓣膜功能不全和静脉阻塞。 这 第二个具体目标是评估敏感性、特异性和 静脉曲张的传统体征和症状的预测价值 三类静脉疾病体征中每一类的疾病 要评估的症状包括疼痛、瘙痒、肿胀和水肿， 沉重、抽筋、夜间不安腿、色素沉着、硬结、 溃疡和特伦德伦堡试验。 第三个具体目标是 评估上述三类静脉的危险因素 疾病。 需要评估的风险因素包括年龄；性别;种族;社会- 经济状况；高度;重量;肥胖;锻炼;血压; 日常活动中站立与坐着；静脉家族史 疾病;吸烟；饮酒量；饮食;便秘; 紧身衣服；使用阿司匹林；使用选定的其他药物； 有疝气、扁平足或其他与此相关的疾病史 结缔组织松弛；平价;雌激素或孕激素的硒；年龄在 初潮;绝经年龄；以及伴随的动脉疾病。 第四个 具体目的是评估发病率和干扰程度 因静脉疾病导致的日常活动，使用质量 加州大学圣地亚哥分校开发的幸福感 (QWB) 量表。 这项研究应该提供对周边范围的准确估计 静脉疾病，有助于更有效的诊断，可以深入了解 如何通过风险因素来预防或改善这种情况 修改，并将提供每日负担的定量估计 这种疾病强加于患者。