IMPROVED RADIOIODINATION METHODS FOR RADIOIMMUNOTHERAPY

改进的放射免疫治疗的放射碘定位方法

• 批准号: 2010451
• 负责人: SERENGULAM V GOVINDAN
• 金额: $ 10万
• 依托单位: IMMUNOMEDICS, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 1997-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2010451
• 关键词: antigen antibody reaction; antitumor antibody; athymic mouse; bioengineering /biomedical engineering; combination cancer therapy; drug design /synthesis /production; immunoconjugates; iodine; method development; monoclonal antibody; neoplasm /cancer immunotherapy; neoplasm /cancer radionuclide therapy; neoplastic cell; pharmacokinetics; radionuclides; radiopharmacology; yttrium

项目成果

Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model.

抗神经胶质瘤间充质细胞外基质 131I 放射性标记鼠单克隆抗体在人神经胶质瘤异种移植模型中的治疗效果。

• 发表时间: 1988
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Lee,YS;Bullard,DE;Zalutsky,MR;Coleman,RE;Wikstrand,CJ;Friedman,HS;Colapinto,EV;Bigner,DD
• 通讯作者: Bigner,DD

Labeling of monoclonal antibodies with diethylenetriaminepentaacetic acid-appended radioiodinated peptides containing D-amino acids.

使用附加有二亚乙基三胺五乙酸的含有 D-氨基酸的放射性碘标记的肽标记单克隆抗体。

• DOI: 10.1021/bc980075g
• 发表时间: 1999
• 期刊: Bioconjugate chemistry.
• 作者: Govindan,SV;Mattes,MJ;Stein,R;McBride,BJ;Karacay,H;Goldenberg,DM;Hansen,HJ;Griffiths,GL
• 通讯作者: Griffiths,GL

The localisation of radiolabelled murine monoclonal antibody 81C6 and its Fab fragment in human glioma xenografts in athymic mice.

• DOI: 10.3109/02688698808992668
• 发表时间: 1988-01-01
• 期刊: British journal of neurosurgery
• 影响因子: 1.1
• 作者: Colapinto, E V;Lee, Y S;Bigner, D D
• 通讯作者: Bigner, D D

Improved iodine radiolabels for monoclonal antibody therapy.

• 发表时间: 2003
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: R. Stein;S. Govindan;M. Mattes;Susan S. Chen;L. Reed;G. Newsome;B. Mcbride;G. Griffiths;H. Hansen;D. Goldenberg

Successful therapy of a human lung cancer xenograft using MAb RS7 labeled with residualizing radioiodine.

使用残留放射性碘标记的 MAb RS7 成功治疗人类肺癌异种移植物。

• DOI: 10.1016/s1040-8428(01)00106-8
• 发表时间: 2001
• 期刊: Critical reviews in oncology/hematology.
• 作者: Stein,R;Govindan,SV;Chen,S;Reed,L;Spiegelman,H;Griffiths,GL;Hansen,HJ;Goldenberg,DM
• 通讯作者: Goldenberg,DM