CHILDRENS CANCER GROUP

儿童癌症组

• 批准号: 2007309
• 负责人: LORRIE F ODOM
• 金额: $ 10.72万
• 依托单位: CHILDREN'S HOSPITAL OF DENVER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-05 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2007309
• 关键词: Wilms' tumor; acute lymphocytic leukemia; acute myelogenous leukemia; asparaginase; astrocytoma; child (0-11); cis platinum compound; clinical trials; colony stimulating factor; combination cancer therapy; combination chemotherapy; cooperative study; cytosine arabinoside; doxorubicin; etoposide; growth factor; human subject; human therapy evaluation; ifosfamide; lymphokines; mitoxantrone; neoplasm /cancer chemotherapy; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; neuroblastoma; osteosarcoma; pediatric neoplasm /cancer; pelvis neoplasms; peritoneum neoplasm; sarcoma

The Children's Hospital, Denver, has participated in the WP Cancer Group as a full member since 1980. Since that time, we have participated in the majority of group wide trials and have consistently been in the top half of institutions in numbers of patients entered on CCG protocols. Several members of our staff have important leadership positions within CCG: Dr. Gerald Haase was named Group Vice Chairman in 1991 and he is also Chairman of the Surgery Discipline Committee. Dr. Odom is a member of the AMC Steering Committee and the AML Strategy Group. Our clinical Research Associate was recently appointed to the newly formed CCG Data Management Committee. Our institution was chosen as one of five across the country to participate in cooperative pilot studies for the treatment of intermediate and poor prognosis newly diagnosed acute lymphoblastic leukemia. Additionally, our nurses have been very active in CCG protocol committees. Our Cytogeneticist and two cardiologists actively participate in the Cytogenetics and Cardiology Committees. The Children;s Hospital, Denver, has brought to the group concepts in the area of induction therapy for acute myeloid leukemia and treatment of high grade astrocytoma. We have been conducting a single institution pilot study incorporating intraarterial Cis Platinum and continuous infusion Adriamycin for the treatment of newly diagnosed osteosarcoma since 1988 (initiated in hiatus period between open front line CCG protocols for treatment of this resectable solid tumors in children. We have experience with nearly 50 patients so treated. This data has been evaluated by the CCG Radiation Therapy and Surgery Committees and is in manuscript preparation. This modality will soon be open for group wide participation. Patients have in the past and will continue to be referred to this institution for this form of treatment. Our Data Management section consistently ranks as one of the best in CCG and we have therefore served as advisors and consultants to other CCG institutions and potential members. Additionally, we are supporting, through profit monies, along with a few other CCG institutions, a computer expert who has designed a software program for management of CCG protocol data, to install this system in our institution to serve as a pilot for CCG of this mechanism of information handling. We have several young investigators with a broad range of interests who are eager to join CCG protocol committees. Our institution has been audited four times, once with an NCI observer for compliance with research requirements and found to have no deviations from Federal regulations.

丹佛儿童医院参加了WP癌症组 自1980年以来作为正式成员。从那时起，我们参加了 大多数小组广泛的试验，并且一直处于最高状态 在CCG方案中输入的患者人数中有一半的机构。 我们的几个员工都有重要的领导职务 CCG：杰拉尔德·哈斯（Gerald Haase）博士于1991年被任命为团体副主席，他是 也是手术学科委员会主席。 奥多姆博士是会员 AMC指导委员会和AML策略小组的成员。 我们的临床 研究助理最近被任命为新成立的CCG数据 管理委员会。 我们的机构被选为五个 该国参加合作试点研究以进行治疗 新诊断的急性淋巴细胞的预后和不良预后 白血病。 此外，我们的护士在CCG方案中非常活跃 委员会。 我们的细胞遗传学家和两位心脏病学家积极 参加细胞遗传学和心脏病学委员会。 儿童医院，丹佛，已将 急性髓样白血病的诱导疗法和治疗 高级星形细胞瘤。 我们一直在开展一个机构 试点研究，结合了核内顺式铂和连续 输注阿霉素用于治疗新诊断的骨肉瘤 自1988年以来（在敞开前线CCG之间的中断期开始 治疗儿童可切除的实体瘤的方案。 我们 有近50名受过治疗的患者的经验。 这个数据已经 通过CCG放射疗法和手术委员会评估，并在 手稿准备。 这种方式将很快开放 参与。 患者过去有，并且会继续 转交给该机构进行这种形式的治疗。 我们的数据管理部分始终排名为CCG中最好的之一 因此，我们曾担任其他CCG的顾问和顾问 机构和潜在成员。 此外，我们支持 通过利润资金以及其他一些CCG机构 设计了用于管理CCG的软件程序的计算机专家 协议数据，在我们机构中安装此系统以作为 该信息处理机理的CCG飞行员。 我们有几个 渴望加入的年轻调查员 CCG协议委员会。 我们的机构已经过四次审计， 一旦与NCI观察员遵守研究要求， 发现与联邦法规没有偏差。