EFFECTS OF RETINOIDS ON CALCIUM METABOLISM AND BONE MINERALIZATION

类维生素A对钙代谢和骨矿化的影响

• 批准号: 6247070
• 负责人: LEONARD M MILSTONE
• 金额: $ 2.68万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6247070
• 关键词: 13 cis retinoate; acne; bone density; bone imaging /visualization /scanning; calcium metabolism; clinical research; drug adverse effect; human subject; human therapy evaluation; longitudinal human study; male; normal ossification; outcomes research; skin disorder chemotherapy; urinalysis; vitamin therapy

Effect of 13-cis retinoic acid on bone mineral density will be assessed in a group of young men receiving customary dose of Accutane for treatment of cystic acne. QDR bone scan and oral calcium tolerance test will be performed prior to and at the conclusion of the six-month course of treatment. These measurements will also be made on an equal number of untreated controls.

13-顺式视黄酸对骨矿物质密度的影响将在 一组接受常规剂量维甲酸治疗的年轻男性 囊肿性痤疮。 QDR 骨扫描和口服钙耐受测试将 在为期六个月的课程之前和结束时进行 治疗。 这些测量也将在相同数量的 未经处理的对照。