MEMBRANE DISORDERS IN ALCOHOLISM

酗酒中的膜疾病

• 批准号: 6246562
• 负责人: Ivan Diamond
• 金额: $ 3.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-03 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246562
• 关键词: alcoholism /alcohol abuse; biomarker; clinical research; cyclic AMP; disease /disorder proneness /risk; genetic markers; human subject; lymphocyte; purinergic receptor; receptor expression; tissue /cell culture

Ethanol-sensitive adenosine receptor-dependent cAMP production occurs in nerve cells and lymphocytes. This system is stimulated acutely by ethanol, and inhibited by chronic exposure to ethanol. In this study, cAMP production is measured in freshly isolated lymphocytes as a biologic marker of alcoholism and in cultured lymphocytes as a possible phenotypic marker for patients who might be at risk to develop alcoholism.

乙醇敏感的腺苷受体依赖性 cAMP 产生发生在 神经细胞和淋巴细胞。 该系统受到强烈刺激 乙醇，并因长期接触乙醇而受到抑制。 在这项研究中， 作为生物制剂，在新鲜分离的淋巴细胞中测量 cAMP 的产生 酒精中毒的标志物和培养的淋巴细胞作为可能的表型 可能有酗酒风险的患者的标记。