ALCOHOL DRINKING AND RISK OF CEREBROVASCULAR DISEASE

饮酒与脑血管疾病的风险

• 批准号: 2457490
• 负责人: ARTHUR L KLATSKY
• 金额: $ 22.3万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2457490
• 关键词: African American; Asian Americans; age difference; alcoholic beverage consumption; artery occlusion; blood glucose; blood pressure; case history; caucasian American; cerebral hemorrhage; cerebral ischemia /hypoxia; cerebrovascular disorders; cholesterol; clinical research; coronary disorder; disease /disorder proneness /risk; gender difference; hospital utilization; human mortality; human subject; physical chemical interaction; racial /ethnic difference; statistics /biometry; venous thrombosis

APPLICANT'S ABSTRACT: Cerebrovascular disease (CVD) is the third leading causes of death and a leading cause of major physical disability in the U.S. Control of hypertension is credited for substantial reduction in CVD incidence; thus, delineation of other modifiable CVD risk traits is important. Heavy alcohol drinking increases risk of hemorrhagic CVD, but its role in occlusive CVD is less clear. The roles of lighter drinking and type of alcoholic beverage (wine, liquor, beer) need further study with respect to all types of CVD. Precise diagnosis of CVD types has improved; reviewers call for more large-scale population studies of the alcohol-CVD relations. This project proposes a prospective study in a Northern California, multiethnic, free-living population of 128,934 men and women who supplied detailed alcohol use data at health examinations. These alcohol habits will be studied in relation to subsequent CVD hospitalizations (2500+ persons) and deaths (450+ persons) with analyses for each acute CVD subset (n=8) for the entire cohort, and nested case- control studies for four CVD subsets. Aspects to be studied include total usual alcohol amount, beverage choice, drinking variability/changes and problem drinking. The case-control studies will focus on the interactions of alcohol, various heart conditions, antithrombotic treatment, and CVD risk. Sex/race differences will be a major focus. The results will be useful to alcohol-health investigations and to health professionals who advise the public.

申请人的摘要：脑血管疾病（CVD）是第三大领先 死亡原因和主要的身体残疾的主要原因 美国对高血压的控制被认为是大幅减少 CVD发病率；因此，划定其他可修改的CVD风险特征是 重要的。 大量饮酒会增加出血性CVD的风险，但 它在闭塞CVD中的作用尚不清楚。 饮酒的角色 和酒精饮料的类型（葡萄酒，酒，啤酒）需要进一步研究 关于所有类型的CVD。 CVD类型的精确诊断具有 改进；审稿人呼吁对更多的大规模人口研究 酒精-CVD关系。 该项目提出了一项前瞻性研究 北加州，128,934人的多种族，自由生活人口 以及在健康检查中提供详细饮酒数据的妇女。 这些酒精习惯将与随后的CVD进行研究 分析的住院（2500多人）和死亡（450多人） 对于整个队列的每个急性CVD子集（n = 8），并嵌套的情况 四个CVD子集的对照研究。 要研究的方面包括 总体酒精量，饮料选择，饮酒变异性/变化 和饮酒问题。 案件对照研究将重点放在 酒精，各种心脏病，抗血栓形成的相互作用 治疗和CVD风险。性别/种族差异将是主要重点。 这 结果将对酒精健康调查和健康有用 建议公众的专业人士。