SUDDEN DEATH AND PSYCHOTROPIC MEDICATION IN YOUTH

青少年猝死和精神药物治疗

• 批准号: 2416196
• 负责人: MADELYN S GOULD
• 金额: $ 41.87万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2416196
• 关键词: adolescence (12-20); clinical research; clonidine; combination chemotherapy; death; drug adverse effect; human data; medical records; mental disorder chemotherapy; methylphenidate; middle childhood (6-11); postmortem; psychopharmacology; sudden cardiac death; tricyclic antidepressant; vehicular accident

DESCRIPTION (Adapted from applicant's abstract): The most serious "side effect" of a medication is death. If the patient is a child or adolescent and the medication is being prescribed for a non-life threatening psychiatric condition, such a death is especially tragic. Therefore, even the suspicion of an association between a psychotropic medication and death among children or adolescents may have major ramifications for the use of the drug. If the association is real, restriction of the use of the medication may be warrant-ed. If the association is not real, the coincidental occurrence of sudden death among individuals taking psychotropic medication, then the medication armamentarium may be needlessly restricted and youngsters in need of treatment may not receive an efficacious therapy. The major aim of this study is to examine the relationship between sudden death in children and adolescents and the use of tricyclic antidepressants (TCA's), or of concomitant methylphenidate and clonidine therapy. The project will involve a post-mortem examination of the medical history of a series of children and adolescents, aged 7 through 19 years, whose deaths were sudden and unexplained. Specifically, a post-mortem of 400 sudden, unexplained deaths among children and adolescents in the United States will be conducted in order to determine the proportion using a TCA or clonidine with methylphenidate at the time of their death. A comparison group of youngsters who died in motor vehicle traffic accidents will allow us to determine whether there is a significant association of unexplained sudden death among young people and TCA use or concomitant methylphenidate and clonidine therapy. The information yielded by this study will provide data upon which rational decisions can be reached concerning the safety of tricyclic antidepressants or combined treatment with methylphenidate and clonidine hydrochloride.

描述（改编自申请人的摘要）：最严肃的“一面” 药物的“效应”就是死亡。如果患者是儿童或青少年 并且该药物是为没有生命危险的患者开的 精神疾病，这样的死亡尤其悲惨。 因此，即使 怀疑精神药物与死亡之间存在关联 儿童或青少年的使用可能会产生重大影响 药物。 如果关联是真实的，则限制使用 可能需要药物治疗。 如果关联不真实，则 服用药物的个体中巧合发生猝死 精神药物，那么药物治疗可能就不必要了 受到限制和需要治疗的青少年可能无法接受治疗 有效的治疗。 本研究的主要目的是检验突发事件之间的关系 儿童和青少年的死亡以及三环类抗抑郁药的使用 （TCA），或哌甲酯和可乐定联合治疗。 这 项目将涉及对死者病史进行尸检 一系列 7 至 19 岁的儿童和青少年，他们的死亡 是突然且无法解释的。 具体来说，对 400 名突然、不明原因死亡的儿童进行了尸检 和美国的青少年将进行以确定 使用 TCA 或可乐定与哌甲酯时的比例 他们的死亡。 机动车死亡青少年的对照组 交通事故将使我们能够确定是否存在重大事故 年轻人不明原因猝死与 TCA 使用的关联或 哌醋甲酯和可乐定联合治疗。 本研究产生的信息将提供合理的数据 可以就三环类抗抑郁药的安全性做出决定 或哌甲酯与盐酸可乐定联合治疗。