Nanoarchitectured multifunctional porous superparamagnetic nanoparticles

纳米结构多功能多孔超顺磁性纳米粒子

• 批准号: DP190102944
• 负责人: Prof Yusuke Yamauchi
• 金额: $ 12.64万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-27 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102944
• 关键词: Nanoarchitectured; multifunctional; porous; superparamagnetic; nanoparticles

This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.

该项目旨在开发一种基于具有过氧化物酶样活性的新型高度多孔超磁性纳米颗粒的新方法来直接检测生物标志物的方法。这些颗粒将用作可分散捕获剂，用于分离生物样品中的特定靶标，以及用于裸眼评估和电化学检测的电催化纳米酶。预计该项目将开发简单，低成本的便携式设备，以分析生物样品中的外泌体和外泌体miRNA。该技术向诊断设备的未来开发将通过实现早期疾病诊断并改善治疗监测来改善患者的预后。