BASAL GANGLIA AND CEREBELLAR INPUTS TO PREFRONTAL CORTEX

基底神经节和小脑对前额皮质的输入

• 批准号: 2033085
• 负责人: Frank A. Middleton
• 金额: $ 1.45万
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2033085
• 关键词: basal ganglia; central neural pathway /tract; cerebellum; motor cortex

The basal ganglia and cerebellum are known to receive inputs from widespread regions of the cerebral cortex, such as the prefrontal, posterior parietal, and temporal lobes. According to one viewpoint, these inputs are integrated in the basal ganglia and cerebellum, and directed to the primary motor cortex, or other cortical motor areas, for use in the control of movement. However, Alexander, Delong, and Strick (1986) and Leiner, Leiner, and Dow (1991, 1993), proposed that significant portions of the output from the basal ganglia and cerebellum target the same regions of the frontal lobe which they receive input from. Thus, according to this scheme, it is possible that several non-motor "loops" exist between the prefrontal cortex and the basal ganglia and cerebellum. Despite the absence of direct anatomical evidence for the existence of such loops, there have been many suggestions about their role in a number of neurological and psychiatric disorders. The proposed experiments are designed to examine the possible existence of the prefrontal loops and the potential role of the basal ganglia and cerebellum in cognitive function. First, it will be determined if the basal ganglia and cerebellum have anatomical connections with regions of the prefrontal cortex that are known to be involved in cognitive function. Second, the degree of separation of these pathways from each other and from previously-described pathways that are involved in motor functions will be determined. To address these issues, retrograde transneuronal transport with the McIntyre-B strain of herpes simplex virus type 1 will be used in cebus monkeys. This technique will enable the direct observation of any pathways in the basal ganglia and cerebellum which are directed to the different prefrontal regions.

众所周知，基底神经节和小脑会从 大脑皮层的广泛区域，例如前额叶， 后顶叶和颞叶。根据一个观点，这些 输入集成在基底神经节和小脑中，并指向 用于主要运动皮层或其他皮质运动区域，可用于 移动的控制。但是，亚历山大，德隆和斯特里克（1986） Leiner，Leiner和Dow（1991，1993）提出了重要的 来自基底神经节和小脑的输出的部分目标 他们收到的额叶的相同区域。因此， 根据该方案，可能有几个非运动“循环” 存在于前额叶皮层与基底神经节和小脑之间。 尽管没有直接解剖学证据的存在 这样的循环，关于它们在一个数字中的作用有很多建议 神经和精神疾病。提出的实验是 旨在检查前额叶环的可能存在和 基底神经节和小脑在认知中的潜在作用 功能。首先，将确定基底神经节和 小脑与前额叶区域有解剖联系 已知参与认知功能的皮质。第二， 这些途径彼此之间的分离程度 以前描述的运动功能涉及的途径将 可以确定。为了解决这些问题，请逆行跨神经元 用单纯疱疹病毒1型的McIntyre-B菌株运输将 用于Cebus猴子。该技术将使直接 观察基底神经节和小脑中的任何途径 针对不同的前额叶区域。

项目成果

New concepts about the organization of basal ganglia output.

关于基底神经节输出组织的新概念。

• 发表时间: 1997
• 期刊: Advances in neurology.
• 作者: Middleton,FA;Strick,PL
• 通讯作者: Strick,PL

Dentate output channels: motor and cognitive components.

齿状输出通道：运动和认知组件。

• DOI: 10.1016/s0079-6123(08)63386-5
• 发表时间: 1997
• 期刊: Progress in brain research
• 作者: Middleton,FA;Strick,PL
• 通讯作者: Strick,PL