MCP-4 AND LEUKOCYTE TRAFFICKING AND ACTIVATION

MCP-4 与白细胞运输和激活

• 批准号: 2002982
• 负责人: MICHELLE DZIEJMAN
• 金额: $ 2.43万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-11 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2002982
• 关键词: cell type; chemokine; cytokine receptors; histology; laboratory mouse; leukocyte activation /transformation; northern blottings; protein structure function

Chemokines are a family of secreted proteins that play a critical regulatory role in directing different types of while blood cells to sites of infection of tissue damage. Regulation of the host immune response by such molecules is important for combating bacterial and viral infection, and for the destruction of transformed cells that could otherwise lead to tumors. However, the improper regulation or expression of these molecules can lead to a dysregulated immune response that can contribute to a variety of inflammatory conditions, including allergic and autoimmune diseases. Consequently, understanding the roles of immuno- regulatory molecules such as chemokines is important for the development of new immunotherapies to inhibit an inappropriate inflammatory response. This knowledge would also be relevant to the design of new vaccines that would augment the host immune response to tumor growth. The aim of this proposal is to further characterize the biological activities of a newly discovered chemokine, MCP-4. Expression of related chemokines is induced by bacterial lipopolysaccarides, which are an active component of Coley's toxins. Some chemokines have been shown to be effective for promoting tumor regression in animal models; others have been associated with asthma, psoriasis and atherosclerosis. Therefore, understanding the properties of MCP-4 is essential for evaluating its therapeutic potential.

趋化因子是一个分泌的蛋白质家族，起着至关重要的作用 调节作用在指导不同类型的同时血细胞到 组织损伤感染部位。 宿主免疫的调节 这种分子的反应对于对抗细菌和 病毒感染，并破坏可能 否则会导致肿瘤。 但是，不当法规或 这些分子的表达会导致免疫失调 可以导致多种炎症条件的反应， 包括过敏和自身免疫性疾病。 最后， 了解免疫调节分子的作用，例如 趋化因子对于新的发展很重要 免疫疗法抑制不当炎症反应。 这些知识也将与新疫苗的设计有关 这将增加宿主对肿瘤生长的免疫反应。 该建议的目的是进一步描述生物学 新发现的趋化因子MCP-4的活动。 表达 相关的趋化因子是由细菌脂多胆碱诱导的，它 是科利毒素的活跃成分。 一些趋化因子具有 被证明可有效促进动物的肿瘤消退 模型；其他人与哮喘，牛皮癣和 动脉粥样硬化。 因此，了解MCP-4的特性是 评估其治疗潜力至关重要。