GLUTEAL ATTACHMENT TO FEMORAL ALLOGRAFTS IN HIP REVISION

髋关节翻修中臀肌与股骨同种异体移植物的附着

• 批准号: 2517412
• 负责人: Grace Elizabeth Pluhar
• 金额: $ 3.53万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2517412
• 关键词: biomechanics; dogs; femur; hip prosthesis; hip surgery; homologous transplantation; musculoskeletal transplantation; striated muscles; tendons

The goals of this research are to increase the functional use and long- term outcome of patients with total hip replacement and hip revision. This study is important due to the necessity of using whole bone segmental allografts to replace proximal femurs that have become deficient in bone stock secondary to menopause, disuse, multiple revision arthroplasties, or that have tumor infiltration. The problem lies in the fact that functional impairment due to inadequate or failed muscle reattachment to the allograft commonly occurs. The working hypothesis for this investigation is that there are specific long-term time-related changes that occur in functional weight-bearing, densitometry, histology, and mechanical characteristics during the incorporation of the allograft tendon and bone following proximal femoral reconstruction that will allow selection of the optimal technique for this reconstruction. Using a canine model, three methods of gluteal attachment to proximal femoral allografts will be compared: (a) a host tendon to allograft tendon attachment using horizontal mattress sutures, (b)a host bone to allograft bone attachment using a cable grip system, and (3) a host bone bicortical half-shell wrapped around the allograft bone without disruption of the host tendon-bone interface. The prosthesis will be cemented to a frozen allograft and this composite cemented to the distal femur after an excision of the proximal 25% of the femur. The animals will be evaluated bimonthly with radiography, densitometry, and functional weight-bearing and at 9 (24 dogs) and 18 (24 dogs) months with histology and mechanical testing following humane euthanasia.

这项研究的目标是增加功能用途和长期 总髋关节置换和髋关节修订的患者的期限结局。 这项研究很重要，因为有必要使用全骨 节段同种异体移植以取代已成为的近端股骨 不足于更年期继发的骨骼库存，废弃，多次修订 关节塑料或肿瘤浸润。问题在于 事实是由于肌肉不足或失败引起的功能障碍 同种异体移植物的重新观察通常发生。工作假设 这项调查是有特定的长期时间有关 功能性重量，密度法，组织学，组织学中发生的变化 同种异体移植期间的机械特性 肌腱和骨骼后股骨近端重建，将允许 选择此重建的最佳技术。使用 犬类模型，三种谷物附着在股骨近端的方法 将比较同种异体移植物：（a）宿主肌腱与同种异体肌腱 使用水平床垫缝合线的附着，（b）宿主骨与同种异体移植 使用电缆握把系统和（3）宿主双皮质的骨附着 半壳包裹在同种异体骨头上，而不干扰 主机肌腱骨接口。假体将巩固 同种异体移植物和该复合材料胶结在股骨远端 近端25％的股骨切除。将评估动物 两次射线照相，光密度法和功能重量 在9（24只狗）和18个月（24只狗）中，有组织学和机械 在人道安乐死之后进行测试。